Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.
Hypertens Res. 2022 Mar;45(3):474-482. doi: 10.1038/s41440-021-00818-8. Epub 2021 Dec 21.
Blood pressure variability (BPV) is associated with the prognosis of cardiovascular diseases. However, it is unclear how BPV is related to various organs. The aim of this study is to investigate the association between BPV and multiple organ functions. A total of three hundred fifteen participants (114 males; mean age: 70 ± 9 years) participated in a community health checkup held in Tarumizu City. Home blood pressure (BP) was measured using a HEM-9700T (OMRON Healthcare, Kyoto, Japan). Day-to-day BPV was evaluated by the coefficient of variation (CV) of home BP measured in the morning for one month. N-terminal pro B-type natriuretic peptide (NT-pro BNP) and high-sensitivity (hs-)troponin T were measured as cardiac biomarkers. Liver stiffness and renal function were evaluated using the Fibrous-4 (Fib4) index and estimated glomerular filtration rate (eGFR), respectively. NT-pro BNP and hs-troponin T were divided by the median value. Fib4 index greater than 2.67 and eGFR less than 60 mL/min/1.73 m were defined as high Fib4 index and low eGFR, respectively. In a multivariable logistic regression analysis, the CV of systolic BP was significantly associated with high NT-pro BNP, high Fib 4 index, and low eGFR, but not with high hs-troponin T. In contrast, the CV of diastolic BP was not associated with low eGFR, and the other three biomarkers had the same results as systolic BP. In conclusion, day-to-day BPV of systolic BP is independently associated with NT-pro BNP, eGFR, and Fib4 index, but not with hs-troponin T. In contrast, diastolic BPV was not found to be associated with eGFR.
血压变异性（BPV）与心血管疾病的预后相关。然而，BPV 与各种器官的关系尚不清楚。本研究旨在探讨 BPV 与多种器官功能之间的关系。共有 315 名参与者（男性 114 名；平均年龄：70±9 岁）参加了在富津市举行的社区健康检查。使用 HEM-9700T（欧姆龙医疗，京都，日本）测量家庭血压（BP）。通过一个月内每天早上测量的家庭 BP 的变异系数（CV）评估日间 BPV。N 末端 pro B 型利钠肽（NT-pro BNP）和高敏（hs）-肌钙蛋白 T 作为心脏生物标志物进行测量。使用 Fibrous-4（Fib4）指数和估算肾小球滤过率（eGFR）评估肝硬度和肾功能。将 NT-pro BNP 和 hs-肌钙蛋白 T 除以中位数。Fib4 指数大于 2.67 和 eGFR 小于 60 mL/min/1.73 m 分别定义为高 Fib4 指数和低 eGFR。在多变量逻辑回归分析中，收缩压的 CV 与高 NT-pro BNP、高 Fib4 指数和低 eGFR 显著相关，但与高 hs-肌钙蛋白 T 无关。相反，舒张压的 CV 与低 eGFR 无关，其他三个生物标志物的结果与收缩压相同。总之，收缩压的日间 BPV 与 NT-pro BNP、eGFR 和 Fib4 指数独立相关，但与 hs-肌钙蛋白 T 无关。相反，未发现舒张压与 eGFR 相关。
