Rodrigues Ana Beatriz, Gismondi Ronaldo Altenburg, Lagoeiro Antonio, Cecilio Angela Mendes, Vasques Delvo, Arita Rafael, Folegatti Thabata, Rosa Maria Luiza
Department of Epidemiology and Statistics, Institute of Public Health, Fluminense Federal University, Rio de Janeiro, Brazil.
Department of Clinical Medicine, Antonio Pedro University Hospital, Fluminense Federal University, Rio de Janeiro, Brazil.
Clin Cardiol. 2018 Jun;41(6):778-781. doi: 10.1002/clc.22953. Epub 2018 May 10.
Blood pressure variability (BPV) has been shown to predict cardiovascular events. Within-visit BPV is the simplest and easiest measure of BPV, but previous studies have shown conflicts as to whether within-visit BPV correlates with target organ damage. We aimed to evaluate whether within-visit BPV correlates with B-type natriuretic peptide (BNP) in a general population.
Within-visit BPV correlates with BNP in a general population.
This was a cross-sectional study that included 633 individuals, randomly selected, age 45 to 99 years, registered in the primary care program from an urban medium-sized town. Patients were scheduled for a single-day visit that consisted of clinical evaluation and laboratory tests. Three blood pressure (BP) readings, 1 minute apart, were done, and within-visit BPV was determined as the coefficient of variation (CV) of the 3 BP measures. Our main outcome was to correlate BNP and within-visit BPV. A multivariable model was estimated using a generalized linear model to evaluate the independent effects of different variables on BNP levels.
The median age was 57 years. Median BNP was 16 pg/mL, and the median systolic and diastolic BP-CV were, respectively, 3.9% and 3.5%. There was a weak but positive correlation between BNP and both systolic BP-CV and diastolic BP-CV (r = 0.107 and P = 0.007 and r = 0.092 and P = 0.019, respectively). In multiple regression equation, systolic BP, diastolic BP-CV, body mass index, and estimated glomerular filtration rate were associated with BNP.
In the present study, there was a positive, albeit weak, correlation between within-visit BPV and BNP. In addition, diastolic BPV was associated with BNP even after adjustment for multiple confounders.
血压变异性（BPV）已被证明可预测心血管事件。就诊期间血压变异性是BPV最简单、最容易测量的指标，但先前的研究对于就诊期间血压变异性是否与靶器官损害相关存在矛盾。我们旨在评估在普通人群中就诊期间血压变异性是否与B型利钠肽（BNP）相关。
在普通人群中就诊期间血压变异性与BNP相关。
这是一项横断面研究，纳入了633名年龄在45至99岁之间、从一个中等规模城市城镇的初级保健项目中随机选取并登记的个体。患者安排进行为期一天的就诊，包括临床评估和实验室检查。间隔1分钟测量三次血压（BP）读数，并将就诊期间血压变异性确定为这三次血压测量值的变异系数（CV）。我们的主要结果是分析BNP与就诊期间血压变异性的相关性。使用广义线性模型估计多变量模型，以评估不同变量对BNP水平的独立影响。
中位年龄为57岁。BNP中位数为16 pg/mL，收缩压和舒张压CV中位数分别为3.9%和3.5%。BNP与收缩压CV和舒张压CV之间均存在弱但正相关（r分别为0.107，P = 0.007；r为0.092，P = 0.019）。在多元回归方程中，收缩压、舒张压CV、体重指数和估算肾小球滤过率与BNP相关。
在本研究中，就诊期间血压变异性与BNP之间存在正相关，尽管较弱。此外，即使在调整多个混杂因素后，舒张压变异性仍与BNP相关。
