Lim Zhu Wei, Chen Wei Liang
Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan, Republic of China.
Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
J Inflamm Res. 2021 Dec 14;14:6833-6844. doi: 10.2147/JIR.S338010. eCollection 2021.
An important clinical feature of metabolic syndrome is abdominal obesity. Microalbuminuria is important in predicting the risk of cardiovascular and renal complications in abdominal obesity patients. However, the association between microalbuminuria polymorphism and abdominal obesity has not been conducted. The objective of this study is to analyze the genetic polymorphism of microalbuminuria in participants with metabolically unhealthy obesity (MUO).
Among 1325 MUO participants, we identified genomic loci underlying those with microalbuminuria, compared to those without microalbuminuria. Single nucleotide polymorphisms (SNPs) were selected with P < 1 × 10 from the Manhattan plot. Multivariable linear regression and analysis of variance were used to analyze the association between different SNP genotypes and microalbuminuria.
The analysis showed homozygous participants for the risk allele A of rs10105606 and Affx-31885823 had 1.978-fold risk and 1.921-fold increased risk of microalbuminuria, respectively. Heterozygous distribution of rs117180252, rs10105606, and Affx-31885823 also increased the risk of microalbuminuria compared to the wild type. Further analysis showed Lipoprotein lipase (, and were the candidate genes associated with lipid metabolism and abdominal obesity.
In conclusion, , and minor allele carriers with abdominal obesity are more susceptible to microalbuminuria, explaining the inter-individual differences of microalbuminuria in MUO patients.
代谢综合征的一个重要临床特征是腹型肥胖。微量白蛋白尿对于预测腹型肥胖患者发生心血管和肾脏并发症的风险很重要。然而，微量白蛋白尿多态性与腹型肥胖之间的关联尚未得到研究。本研究的目的是分析代谢不健康肥胖（MUO）参与者中微量白蛋白尿的基因多态性。
在1325名MUO参与者中，我们确定了有微量白蛋白尿者与无微量白蛋白尿者的潜在基因组位点。从曼哈顿图中选择P<1×10的单核苷酸多态性（SNP）。使用多变量线性回归和方差分析来分析不同SNP基因型与微量白蛋白尿之间的关联。
分析显示，rs10105606风险等位基因A的纯合参与者和Affx-31885823的微量白蛋白尿风险分别增加1.978倍和1.921倍。与野生型相比，rs117180252、rs10105606和Affx-31885823的杂合分布也增加了微量白蛋白尿的风险。进一步分析显示脂蛋白脂肪酶（ 以及 是与脂质代谢和腹型肥胖相关的候选基因。
总之，腹型肥胖的 、 和 次要等位基因携带者更容易发生微量白蛋白尿，这解释了MUO患者微量白蛋白尿的个体差异。
