巴西南部 2 型糖尿病患者中，脂肪量和肥胖相关基因的 rs7204609 多态性与中心性肥胖和微量白蛋白尿呈正相关。

The rs7204609 polymorphism in the fat mass and obesity-associated gene is positively associated with central obesity and microalbuminuria in patients with type 2 diabetes from Southern Brazil.

机构信息

Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Navarra, Spain.

Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

出版信息

J Ren Nutr. 2012 Mar;22(2):228-236. doi: 10.1053/j.jrn.2011.03.004. Epub 2011 Jul 13.

DOI:10.1053/j.jrn.2011.03.004

PMID:21741858

Abstract

OBJECTIVE

Single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) gene, especially the common rs9939609 (A/T) SNP, are associated with body mass index (BMI), diabetes, and metabolic syndrome (MetS). MetS is highly prevalent in patients with type 2 diabetes and has been associated with chronic diabetic complications. Therefore, the aim of this study was to evaluate possible associations of the scarcely investigated rs7204609 (C/T) polymorphism, as well as the rs9939609 (A/T) polymorphism, with MetS and chronic diabetic complications in type 2 diabetic patients from Southern Brazil.

DESIGN

This was a cross-sectional study.

PATIENTS AND METHODS

A total of 236 patients with type 2 diabetes (age: 60.0 ± 10.3 years; diabetes duration: 12.7 ± 8.2 years; 53.4% women) were genotyped for the FTO rs7204609 and rs9939609 polymorphisms (ABI PRISM 7000 Real-Time PCR System). Patients underwent clinical, laboratory, and nutritional evaluation. MetS was defined according to the 2009-Joint Interim Statement.

RESULTS

Carriers of C allele of the rs7204609 polymorphism (CT/CC genotypes, n = 35) were at increased risk for the presence of MetS (odds ratio [OR] = 4.56; 95% CI: 1.04 to 19.9), elevated waist circumference (OR = 8.66; 95% CI: 1.12 to 66.7), BMI: ≥ 30 kg/m(2) (OR = 3.71; 95% CI: 1.71 to 8.02), and microalbuminuria (OR = 2.30; 95% CI: 1.08 to 4.88), adjusted for gender and diabetes duration (P < .05 for all models). The rs9939609 polymorphism was not associated with MetS, elevated waist circumference or BMI, or diabetic complications. Daily energy and nutrient intakes did not differ according to the presence of the polymorphisms.

CONCLUSIONS

The C allele of the rs7204609 polymorphism in the FTO gene increased the chance for the presence of MetS, especially central obesity, and microalbuminuria, independently of energy and nutrient intakes in this sample of type 2 diabetic patients from Southern Brazil.

摘要

目的

脂肪量和肥胖相关基因（FTO）中的单核苷酸多态性（SNP），尤其是常见的 rs9939609（A/T）SNP，与体重指数（BMI）、糖尿病和代谢综合征（MetS）有关。MetS 在 2 型糖尿病患者中发病率很高，并与慢性糖尿病并发症有关。因此，本研究旨在评估在来自巴西南部的 2 型糖尿病患者中，研究相对较少的 rs7204609（C/T）多态性以及 rs9939609（A/T）多态性与 MetS 和慢性糖尿病并发症的可能关联。

设计

这是一项横断面研究。

患者和方法

共对 236 名 2 型糖尿病患者（年龄：60.0±10.3 岁；糖尿病病程：12.7±8.2 年；53.4%为女性）进行了 FTO rs7204609 和 rs9939609 多态性（ABI PRISM 7000 实时 PCR 系统）的基因分型。患者接受了临床、实验室和营养评估。MetS 根据 2009 年联合临时声明进行定义。

结果

rs7204609 多态性 C 等位基因携带者（CT/CC 基因型，n=35）患 MetS 的风险增加（比值比[OR] = 4.56；95%可信区间：1.04 至 19.9），腰围增大（OR = 8.66；95%可信区间：1.12 至 66.7），BMI：≥30kg/m²（OR = 3.71；95%可信区间：1.71 至 8.02）和微量白蛋白尿（OR = 2.30；95%可信区间：1.08 至 4.88），调整性别和糖尿病病程后（所有模型 P <.05）。rs9939609 多态性与 MetS、腰围增大或 BMI 或糖尿病并发症无关。根据多态性的存在，每日能量和营养素摄入没有差异。