Weber W E, Buurman W A, Vandermeeren M M, Medaer R H, Raus J C
Neurology. 1987 Mar;37(3):419-25. doi: 10.1212/wnl.37.3.419.
Cytolytic T lymphocyte precursors (CTL-p) and natural killer precursors (NK-p) in the CSF of 15 MS patients and 11 patients with other neurologic disorders (OND) were quantitatively assessed, using a T-lymphocyte microculture system that allows clonal expansion of all human T cells. CSF CTL-p and NK-p frequencies were higher in patients with OND of inflammatory nature than in patients with noninflammatory OND. In all MS patients, these frequencies were higher in the CSF than in their peripheral blood. Surprisingly, in all patients studied, the CSF contained a substantial number of CTL-p with a helper (CD4+) phenotype.
使用一种能使所有人类T细胞克隆扩增的T淋巴细胞微培养系统，对15例多发性硬化症（MS）患者和11例患有其他神经系统疾病（OND）患者脑脊液中的细胞溶解性T淋巴细胞前体（CTL-p）和自然杀伤前体（NK-p）进行了定量评估。与非炎性OND患者相比，炎性OND患者脑脊液中的CTL-p和NK-p频率更高。在所有MS患者中，脑脊液中的这些频率高于其外周血中的频率。令人惊讶的是，在所有研究的患者中，脑脊液中含有大量具有辅助性（CD4 +）表型的CTL-p。
