2021年中国高危人群加强免疫接种控制新冠病毒变异株的可行性
Feasibility of Booster Vaccination in High-Risk Populations for Controlling Coronavirus Variants - China, 2021.
作者信息
Li Kangguo, Zhao Zeyu, Wei Hongjie, Rui Jia, Huang Jiefeng, Guo Xiaohao, Guo Yichao, Yang Shiting, Abudurusuli Guzainuer, Luo Li, Liu Xingchun, Wang Yao, Xu Jingwen, Zhu Yuanzhao, Yang Meng, Yang Tianlong, Liu Weikang, Deng Bin, Liu Chan, Li Zhuoyang, Li Peihua, Yu Shanshan, Yang Zimei, Su Yanhua, Zhao Benhua, Niu Yan, Chen Tianmu
机构信息
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China.
Université de Montpellier, Montpellier, France; CIRAD, Intertryp, Montpellier, France; IES, Université de Montpellier-CNRS, Montpellier, France.
出版信息
China CDC Wkly. 2021 Dec 3;3(50):1071-1074. doi: 10.46234/ccdcw2021.259.
INTRODUCTION
Vaccination booster shots are completely necessary for controlling breakthrough infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China. The study aims to estimate effectiveness of booster vaccines for high-risk populations (HRPs).
METHODS
A vaccinated Susceptible-Exposed-Symptomatic-Asymptomatic-Recovered/Removed (SEIAR) model was developed to simulate scenarios of effective reproduction number ( ) from 4 to 6. Total number of infectious and asymptomatic cases were used to evaluated vaccination effectiveness.
RESULTS
Our model showed that we could not prevent outbreaks when covering 80% of HRPs with booster unless =4.0 or the booster vaccine had efficacy against infectivity and susceptibility of more than 90%. The results were consistent when the outcome index was confirmed cases or asymptomatic cases.
CONCLUSIONS
An ideal coronavirus disease 2019 (COVID-19) booster vaccination strategy for HRPs would be expected to reach the initial goal to control the transmission of the Delta variant in China. Accordingly, the recommendation for the COVID-19 booster vaccine should be implemented in HRPs who are already vaccinated and could prevent transmission to other groups.
引言
在中国，接种新冠疫苗加强针对于控制严重急性呼吸综合征冠状病毒2（SARS-CoV-2）突破性感染是完全必要的。本研究旨在评估高危人群（HRPs）接种加强针疫苗的有效性。
方法
构建了一个接种疫苗的易感-暴露-有症状-无症状-康复/清除（SEIAR）模型，以模拟有效繁殖数（ ）从4到6的情况。用感染病例和无症状病例总数评估疫苗接种效果。
结果
我们的模型显示，除非 =4.0或加强针疫苗对传染性和易感性的效力超过90%，否则在80%的高危人群接种加强针的情况下无法预防疫情爆发。当结果指标为确诊病例或无症状病例时，结果一致。
结论
预计针对高危人群的理想的2019冠状病毒病（COVID-19）加强针接种策略将达到在中国控制德尔塔变异株传播的初步目标。因此，对于已接种疫苗且能防止传播给其他人群的高危人群，应实施COVID-19加强针疫苗的接种建议。
Zotero 插件