Ghanaati Hossein, Mohammadifard Mahyar, Mohammadifard Mahtab
Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran.
Department of Radiology, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
J Family Med Prim Care. 2021 Oct;10(10):3553-3560. doi: 10.4103/jfmpc.jfmpc_2347_20. Epub 2021 Nov 5.
Liver cancer is one of the most ordinary reasons for death among cancers. Hepatocellular carcinoma (HCC) is the most common type of liver cancer. In spite of the fact that various remedial methods have been approved particularly the survival effects of the transcatheter arterial chemoembolization (TACE) method have been accomplished widely in the HCC treatment. By applying the TACE method correctly, good survival outcomes can be achieved without harmfully affecting the hepatic functions. Transarterial chemoembolization mixes the effect of avascular necrosis (AVN) with the effect of regional chemotherapy those are under the influence of arterial embolization. By knowing the fact that the metastases of liver cancer and also perfusion indices in hepatocellular carcinoma (HCC) are via hepatic arteries, doctors chose the TACE method for the treatment of liver cancer. On the other hand, in this method, the radiologists can easily convey antitumor remedies via the arteries. Anyway, medium-level HCC is a sensitive stage of the heterogeneous disease that many patients suffer from, so specialists must consider it as a hazardous syndrome. The TACE procedure could be applied just in cases that the liver function of patients is appropriate yet, the patient liver portal vein do not have any problems and the patients do not have ascites disorder. This review is aimed to figure out the evident advantages of TACE especially by a comprehensive view on the medium level HCC. Because of that this treatment method is suggested as a first-line remedy. At last, the future landscape of the initial factors of research in managing HCC disorders have been summarized.
肝癌是癌症死亡的最常见原因之一。肝细胞癌(HCC)是最常见的肝癌类型。尽管已经批准了各种治疗方法,特别是经动脉化疗栓塞(TACE)方法的生存效果在HCC治疗中已广泛实现。正确应用TACE方法,可以在不损害肝功能的情况下取得良好的生存结果。经动脉化疗栓塞将无血管坏死(AVN)的效果与区域化疗的效果相结合,这些都受到动脉栓塞的影响。鉴于肝癌的转移以及肝细胞癌(HCC)的灌注指数是通过肝动脉进行的,医生选择TACE方法来治疗肝癌。另一方面,在这种方法中,放射科医生可以很容易地通过动脉输送抗肿瘤药物。无论如何,中期HCC是许多患者所患的异质性疾病的一个敏感阶段,因此专家们必须将其视为一种危险综合征。TACE程序仅适用于患者肝功能尚合适、患者肝门静脉没有任何问题且患者没有腹水紊乱的情况。本综述旨在找出TACE的明显优势,特别是通过对中期HCC的全面观察。因此,这种治疗方法被建议作为一线治疗方法。最后,总结了管理HCC疾病研究初始因素的未来前景。