Kowe Priyanka A, Bhushan Ravi, Wankhade Vaishali H, Singh Rajesh P
Department of Dermato-Venereo-Leprology, Government Medical College and Hospital, Nagpur, Maharashtra, India.
Indian Dermatol Online J. 2021 Nov 22;12(6):892-895. doi: 10.4103/idoj.IDOJ_557_20. eCollection 2021 Nov-Dec.
Chronic acral hyperkeratotic dermatosis includes several conditions such as lichen simplex chronicus (LSC), hypertrophic lichen planus (HLP), psoriasis vulgaris (Ps), acral acanthosis nigricans, acquired zinc deficiency, and necrolytic acral erythema (NAE). LSC, Ps, and HLP respond to conventional treatments such as topical corticosteroids, immuno-modulators such as tacrolimus, and oral methotrexate. Zinc-responsive acral hyperkeratosis is a novel entity that resembles the above mentioned diagnoses clinically but fails to respond to the above treatment options. NAE is a rare condition, commonly associated with hepatitis C virus infection and manifest similar clinical features of zinc-responsive acral hyperkeratosis, but differs histopathologically. Both conditions show a good response to oral zinc supplementation. As there is a paucity of literature on zinc-responsive acral hyperkeratosis, we are highlighting the case.
慢性肢端角化过度性皮肤病包括多种病症，如慢性单纯性苔藓（LSC）、肥厚性扁平苔藓（HLP）、寻常型银屑病（Ps）、肢端黑棘皮病、获得性锌缺乏症以及坏死松解性肢端红斑（NAE）。LSC、Ps和HLP对传统治疗方法有反应，如外用糖皮质激素、免疫调节剂如他克莫司以及口服甲氨蝶呤。锌反应性肢端角化过度是一种新的病症，临床上类似于上述诊断，但对上述治疗方案无反应。NAE是一种罕见病症，通常与丙型肝炎病毒感染相关，表现出与锌反应性肢端角化过度相似的临床特征，但在组织病理学上有所不同。这两种病症对口服补锌均有良好反应。由于关于锌反应性肢端角化过度的文献较少，我们在此突出介绍该病例。
