Cummings Jeffrey L, Ismail Zahinoor, Dickerson Bradford C, Ballard Clive, Grossberg George, McEvoy Bradley, Foff Erin, Atri Alireza
Chambers-Grundy Center for Transformative Neuroscience Department of Brain Health School of Integrated Health Sciences University of Nevada Las Vegas Las Vegas Nevada USA.
Hotchkiss Brain Institute University of Calgary O'Brien Institute for Public Health University of Calgary Calgary Alberta Canada.
Alzheimers Dement (Amst). 2021 Dec 7;13(1):e12254. doi: 10.1002/dad2.12254. eCollection 2021.
Hallucinations and delusions (H+D) are common in dementia, but screening for these symptoms-especially in busy clinical practices-is challenging.
Six subject matter experts developed the DRP3™ screen, a novel valid tool to detect H+D in dementia, assessed its content validity through alignment with DRP reference assessments (Scale for the Assessment of Positive Symptoms-Hallucinations + Delusions, Neuropsychiatric Inventory-Questionnaire, International Psychogeriatric Association Criteria), and retrospectively investigated its ability to detect H+D in HARMONY trial (NCT03325556) enrollees.
All items from three reference assessments demonstrated significant agreement with the DRP3 screen among raters ( < .0001). Retrospectively applying the DRP3 screen to HARMONY identified all (N = 392) trial enrollees.
The DRP3 screen, comprising three yes/no questions, is a content-valid tool for detecting H+D in dementia that aligned with current reference assessments and successfully identified trial participants when retrospectively applied to a completed trial. Within busy practice constraints, the DRP3 screen provides a brief tool for sensitive detection of H+D in patients with dementia.
幻觉和妄想（H+D）在痴呆症中很常见，但筛查这些症状——尤其是在繁忙的临床实践中——具有挑战性。
六位主题专家开发了DRP3™筛查工具，这是一种用于检测痴呆症中H+D的新型有效工具，通过与DRP参考评估（阳性症状评估量表——幻觉+妄想、神经精神科问卷、国际老年精神病学协会标准）进行比对来评估其内容效度，并回顾性研究其在HARMONY试验（NCT03325556）参与者中检测H+D的能力。
三项参考评估中的所有项目在评估者之间均与DRP3筛查工具显示出显著一致性（<0.0001）。将DRP3筛查工具回顾性应用于HARMONY试验时识别出了所有（N=392）试验参与者。
DRP3筛查工具由三个是/否问题组成，是一种检测痴呆症中H+D的内容有效的工具，与当前参考评估一致，并且在回顾性应用于已完成的试验时成功识别出了试验参与者。在繁忙的实践限制下，DRP3筛查工具为敏感检测痴呆症患者的H+D提供了一种简短的工具。
