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羟基脲在新型冠状病毒肺炎治疗中的应用

The Use of Hydroxyurea in the Treatment of COVID-19.

作者信息

Foster Melissa Robin Bowman, Hijazi Ali Atef, Opoku Rebecca, Varghese Priya, Li Chun

机构信息

Winston-Salem State University, Winston-Salem, NC, USA.

出版信息

J Crit Care Med (Targu Mures). 2021 Nov 6;7(4):312-317. doi: 10.2478/jccm-2021-0019. eCollection 2021 Oct.

Abstract

INTRODUCTION

The rapid worldwide spread of COVID-19 motivated medical professionals to pursue and authenticate appropriate remedies and treatment protocols. This article aims to analyze the potential benefits of one treatment protocol developed by a group of care providers caring for severe COVID-19 patients.

METHODS

The clinical findings of COVID-19 patients who were transferred to a specialized care hospital after unsuccessful treatment in previous institutions, were analyzed. The specialized care hospital used a treatment protocol including hydroxyurea, a medication commonly used for sickle cell treatment, to improve respiratory distress in the COVID-19 patients. None of the COVID-19 patients included in the analyzed data were diagnosed with sickle cell, and none had previously taken hydroxyurea for any other conditions.

RESULTS

In all presented cases, patients reverted to their baseline respiratory health after treatment with the hydroxyurea protocol. There was no significant difference in the correlation between COVID-19 and hydroxyurea. However, deaths were extremely low for those taking hydroxyurea.

CONCLUSIONS

Fatality numbers were extremely low for those taking hydroxyurea; death could be attributed to other underlying issues.

摘要

引言

新冠病毒病(COVID-19)在全球的迅速传播促使医学专业人员寻求并验证合适的治疗方法和治疗方案。本文旨在分析一组照料重症COVID-19患者的医护人员所制定的一种治疗方案的潜在益处。

方法

对先前机构治疗失败后转至一家专科医院的COVID-19患者的临床结果进行分析。该专科医院采用了一种治疗方案,其中包括用于镰状细胞病治疗的常用药物羟基脲,以改善COVID-19患者的呼吸窘迫。分析数据中纳入的COVID-19患者均未被诊断为镰状细胞病,且此前均未因任何其他病症服用过羟基脲。

结果

在所有呈现的病例中,患者经羟基脲方案治疗后呼吸健康恢复至基线水平。COVID-19与羟基脲之间的相关性无显著差异。然而,服用羟基脲者的死亡率极低。

结论

服用羟基脲者的死亡人数极低;死亡可能归因于其他潜在问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1a1/8647674/30bd89f57ac7/jccm-07-312-g001.jpg

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