State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
Food Funct. 2022 Jan 24;13(2):688-701. doi: 10.1039/d1fo03677g.
Inflammatory bowel disease is associated with intestinal homeostasis dysregulation and gut microbiota dysbiosis. This study aimed to investigate the protective effect of extracts ( polysaccharides (GAP) and 75% ethanol extracts (GAE)) on colon inflammation and elucidate the therapeutic mechanism. GAP and GAE showed considerable protective effects against dextran sodium sulfate (DSS)-induced colitis, as demonstrated by reduced mortality, body weight, disease activity index score, colon length, and histological score. Through GAP and GAE administration, the destroyed intestinal barrier recovered to normal, as did intestinal inflammation. We also confirmed that GAP administration promoted the recovery of colitis in a gut microbiota-dependent manner. The similarity between GAP and GAE administration was that they both altered the disordered gut microbiota damaged by DSS, exhibiting reduced abundance of _, , and , but the modulation of the gut microbiota was distinct between GAP and GAE.
炎症性肠病与肠道内稳态失调和肠道微生物失调有关。本研究旨在探讨提取物（多糖（GAP）和 75%乙醇提取物（GAE））对结肠炎症的保护作用，并阐明其治疗机制。GAP 和 GAE 对葡聚糖硫酸钠（DSS）诱导的结肠炎表现出相当大的保护作用，表现为死亡率、体重、疾病活动指数评分、结肠长度和组织学评分降低。通过 GAP 和 GAE 给药，破坏的肠道屏障恢复正常，肠道炎症也是如此。我们还证实，GAP 给药以依赖于肠道微生物群的方式促进结肠炎的恢复。GAP 和 GAE 给药的相似之处在于，它们都改变了 DSS 破坏的紊乱肠道微生物群，表现为 、 和 _ 的丰度降低，但 GAP 和 GAE 对肠道微生物群的调节是不同的。
