Yonekura Y, Tamaki N, Senda M, Nohara R, Kambara H, Konishi Y, Koide H, Kureshi S A, Saji H, Ban T
Am Heart J. 1987 Mar;113(3):645-54. doi: 10.1016/0002-8703(87)90702-2.
In order to evaluate the detectability of coronary artery disease (CAD) with positron-emission computed tomography (PET), we performed 13N-ammonia myocardial PET scanning at rest and with exercise loading in 20 normal subjects and 40 patients with CAD, by means of a high-resolution, multi-slice, whole-body PET scanner. Myocardial PET scanning was performed 3 minutes after injection of 13N-ammonia at rest and during exercise. The circumferential profile analysis of resting PET images revealed regional hypoperfusion in 96% of CAD patients with previous myocardial infarction and in 29% of those without infarction. Exercise PET studies showed high sensitivity (93%) in detecting CAD without myocardial infarction, whereas no abnormal hypoperfusion was detected in normal subjects. Segmental analysis of regional myocardial perfusion with exercise stress identified 67 of 75 stenosed vessels (89%). We conclude that 13N-ammonia myocardial PET with exercise loading provides high-quality tomographic images of regional myocardial perfusion and is a valuable technique for detecting CAD.
为了评估正电子发射计算机断层显像（PET）对冠状动脉疾病（CAD）的检测能力，我们使用高分辨率、多层全身PET扫描仪，对20名正常受试者和40名CAD患者进行了静息和运动负荷下的13N-氨心肌PET扫描。在静息和运动状态下，于注射13N-氨3分钟后进行心肌PET扫描。静息PET图像的圆周轮廓分析显示，既往有心肌梗死的CAD患者中有96%出现局部灌注不足，无梗死的患者中有29%出现局部灌注不足。运动PET研究显示，在检测无心肌梗死的CAD时具有高敏感性（93%），而在正常受试者中未检测到异常灌注不足。运动负荷下局部心肌灌注的节段分析发现，75条狭窄血管中有67条（89%）。我们得出结论，运动负荷下的13N-氨心肌PET可提供高质量的局部心肌灌注断层图像，是检测CAD的一项有价值的技术。
