Corbett J R, Ficaro E P
Department of Internal Medicine, The University of Michigan Medical Center, Ann Arbor, USA.
J Nucl Cardiol. 1999 Jan-Feb;6(1 Pt 1):54-68. doi: 10.1016/s1071-3581(99)90065-x.
Rather than the introduction of a heralded technologic advancement in cardiac SPECT imaging challenging the accuracy of PET perfusion imaging, the commercial introduction of attenuation correction has been met with at least as many negative as positive reports. Some studies have reported significant improvements in specificity or specificity and sensitivity, especially for high-risk patterns of coronary artery disease; others have reported no improvement or a decrease in accuracy resulting from the introduction of troublesome artifacts. Although this review has attempted to emphasize the positive aspects of attenuation-corrected cardiac SPECT perfusion imaging and the potential for improved patient care it may provide, several negative reports continue to appear. Still there has been sufficient positive data reported to suggest that with fully developed, accurate, and robust correction methods, significant gains in SPECT assessments of the presence and extent of CHD, patient risk, and myocardial viability can be anticipated. Ultimately attenuation correction for cardiac SPECT should have a positive impact on the management of patients with coronary artery disease with important savings in lives and health care dollars.
在心脏单光子发射计算机断层显像（SPECT）成像中，一项备受瞩目的技术进步的引入并未对正电子发射断层显像（PET）灌注成像的准确性构成挑战，而衰减校正技术的商业推广所带来的负面报道至少与正面报道一样多。一些研究报告称，特异性或特异性及敏感性有显著提高，尤其是对于冠状动脉疾病的高危模式；另一些研究则报告称，引入麻烦的伪影后准确性没有提高或有所下降。尽管本综述试图强调衰减校正后的心脏SPECT灌注成像的积极方面以及它可能为改善患者护理带来的潜力，但仍有一些负面报道不断出现。不过，已有足够多的正面数据表明，采用充分发展、准确且稳健的校正方法，有望在冠心病的存在和范围、患者风险以及心肌活力的SPECT评估方面取得显著进展。最终，心脏SPECT的衰减校正应该会对冠状动脉疾病患者的管理产生积极影响，在挽救生命和节省医疗费用方面意义重大。
