Durivage A, Miliaressis E
Behav Neurosci. 1987 Feb;101(1):57-61. doi: 10.1037//0735-7044.101.1.57.
The purpose of this research was to determine whether brain stimulation reward and exploration are induced by activation of the same set of neurons along the medial forebrain bundle. The behavioral version of the collision test was utilized with electrodes in the lateral hypothalamus (LH) and the ventral tegmental area (VTA). A collision effect obtained between LH and VTA in one behavior at the exclusion of the other was treated as evidence of the involvement of two different sets of fibers. In 4 rats, a collision effect was observed only in self-stimulation, whereas in 1 rat, a collision was obtained in exploration at the exclusion of self-stimulation. Three animals showed no collision in either behavior. These data suggest that coexistence of self-stimulation and exploration following medial forebrain bundle stimulation can be explained by current spread on two different sets of fibers.
本研究的目的是确定沿内侧前脑束激活同一组神经元是否会诱发脑刺激奖赏和探索行为。采用行为学版本的碰撞试验，将电极置于外侧下丘脑（LH）和腹侧被盖区（VTA）。在一种行为中LH和VTA之间获得碰撞效应而排除另一种行为时，这被视为两组不同纤维参与的证据。在4只大鼠中，仅在自我刺激时观察到碰撞效应，而在1只大鼠中，在排除自我刺激的探索行为中获得了碰撞效应。三只动物在两种行为中均未表现出碰撞效应。这些数据表明，内侧前脑束刺激后自我刺激和探索行为的共存可以用电流在两组不同纤维上的扩散来解释。
