School of Life Science, South China Normal University, Guangzhou, 510631, China.
Guangzhou Key Laboratory of Spectral Analysis and Functional Probes, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
J Mater Chem B. 2022 Jan 19;10(3):418-429. doi: 10.1039/d1tb02056k.
Breast cancer is one of the most common cancers in the world with tumor heterogeneity. Currently, cancer treatment mainly relies on surgical intervention, chemotherapy, and radiotherapy, for which the side effects, drug resistance and cost need to be resolved. In this study, we develop a natural medicine targeted therapy system. Phosphatidylcholine (PC), doxorubicin (DOX), procyanidin (PA), and epigallocatechin gallate (EGCG) are assembled and PC@DOX-PA/EGCG nanoparticles (NPs) are obtained. In addition, the HER2, ER and PR ligands were grafted on the surface of the NPs to acquire the targeted nanoparticles NP-ER, NP-ER-HER2, and NP-ER-HER2-PR. The physicochemical properties of the nanoparticles were detected and it was found that the nanoparticles are spherical and less than 200 nm in diameter. Furthermore, and results indicate that the nanoparticles can target BT-474, MCF-7, EMT-6, and MDA-MB-231 breast cancer cells, effectively inhibiting the growth of the breast cancer cells. In short, this research will provide some strategies for the treatment of heterogeneous breast cancer.
乳腺癌是世界上最常见的癌症之一，具有肿瘤异质性。目前，癌症的治疗主要依赖于手术干预、化疗和放疗，但其副作用、耐药性和成本需要得到解决。在本研究中，我们开发了一种天然药物靶向治疗系统。将磷脂酰胆碱（PC）、阿霉素（DOX）、原花青素（PA）和表没食子儿茶素没食子酸酯（EGCG）进行组装，得到 PC@DOX-PA/EGCG 纳米颗粒（NPs）。此外，将 HER2、ER 和 PR 配体接枝到 NPs 的表面，获得靶向纳米颗粒 NP-ER、NP-ER-HER2 和 NP-ER-HER2-PR。检测了纳米颗粒的理化性质，发现纳米颗粒呈球形，直径小于 200nm。此外，和结果表明，纳米颗粒可以靶向 BT-474、MCF-7、EMT-6 和 MDA-MB-231 乳腺癌细胞，有效抑制乳腺癌细胞的生长。总之，本研究将为异质性乳腺癌的治疗提供一些策略。
