Laboratory of Natural Products & Drug Discovery, Center CEBIM, Department of Basic Sciences, Faculty of Medicine, Universidad de La Frontera, Temuco 4780000, Chile.
Departamento de Ciencias Biológicas y Químicas, Facultad de Recursos Naturales, Universidad Católica de Temuco, Rudecindo Ortega, Temuco 02950, Chile.
Int J Mol Sci. 2023 Jun 27;24(13):10737. doi: 10.3390/ijms241310737.
Breast cancer is one of the most diagnosed cancers worldwide, with an incidence of 47.8%. Its treatment includes surgery, radiotherapy, chemotherapy, and antibodies giving a mortality of 13.6%. Breast tumor development is driven by a variety of signaling pathways with high heterogeneity of surface receptors, which makes treatment difficult. Epigallocatechin-3-gallate (EGCG) is a natural polyphenol isolated as the main component in green tea; it has shown multiple beneficial effects in breast cancer, controlling proliferation, invasion, apoptosis, inflammation, and demethylation of DNA. These properties were proved in vitro and in vivo together with synergistic effects in combination with traditional chemotherapy, increasing the effectiveness of the treatment. This review focuses on the effects of EGCG on the functional capabilities acquired by breast tumor cells during its multistep development, the molecular and signal pathways involved, the synergistic effects in combination with current drugs, and how nanomaterials can improve its bioavailability on breast cancer treatment.
乳腺癌是全球最常见的癌症之一，发病率为 47.8%。其治疗方法包括手术、放疗、化疗和抗体治疗，死亡率为 13.6%。乳腺癌的发展是由多种信号通路驱动的，表面受体具有高度异质性，这使得治疗变得困难。表没食子儿茶素没食子酸酯（EGCG）是一种从绿茶中分离出来的天然多酚，它在乳腺癌中有多种有益作用，可控制增殖、侵袭、凋亡、炎症和 DNA 的去甲基化。这些特性在体外和体内都得到了证实，并且与传统化疗联合使用具有协同作用，提高了治疗效果。本综述重点介绍了 EGCG 对乳腺癌多步发展过程中肿瘤细胞获得的功能特性的影响，涉及的分子和信号通路，与现有药物联合使用的协同作用，以及纳米材料如何提高其在乳腺癌治疗中的生物利用度。
