Department of Special Medical, Chengdu BOE hospital, Chengdu, Sichuan Province, China.
Department of Neurology, The Air Force Hospital of Western Theater Command, Chengdu, Sichuan Province, China.
Medicine (Baltimore). 2021 Dec 23;100(51):e28161. doi: 10.1097/MD.0000000000028161.
With the aging population, the prevalence and incidence of dementia disease will continue to rise, and the associated economic burden is increasing as well. However, the available anti-dementia therapeutic arsenal is limited. Meanwhile, magnesium valproate (VPM) as an adjuvant therapy had a general positive effect on the cognitive function and psychiatric symptoms of patient with dementia (PwD). At present, there is lack of meta-analysis focusing on cognitive improvement and disease-modifying about VPM-assisted therapy in the present peer-reviewed literature. Thus, we aimed to likely analyze the efficacy and safety of VPM adjuvant therapy of PwD.
We will research MEDLINE via PubMed, Cochrane Library, EBSCO, Embase, China National Knowledge (CNKI) and Wan fang databases to gather relevant data on VPM assistant therapy on the PwD. Meta-analysis will be performed using Stata16.0 software.
We aim to evaluate the efficacy and safety of VPM in the adjuvant treatment of PwD.
VPM maybe plays an active role in the treatment of dementia patients and this research will provide reliable evidence for clinicians in therapy of PwD.
INPLASY2021110038 (DOI: 10.37766/inplasy2021.11.0038).
随着人口老龄化，痴呆症的患病率和发病率将继续上升，相关的经济负担也在增加。然而，现有的抗痴呆症治疗手段有限。同时，镁丙戊酸盐（VPM）作为辅助治疗对痴呆症患者（PwD）的认知功能和精神症状有普遍的积极影响。目前，在现有的同行评议文献中，缺乏关于 VPM 辅助治疗对认知改善和疾病修饰作用的荟萃分析。因此，我们旨在分析 VPM 辅助治疗 PwD 的疗效和安全性。
我们将通过 PubMed 的 MEDLINE、Cochrane 图书馆、EBSCO、Embase、中国国家知识基础设施（CNKI）和万方数据库检索有关 VPM 辅助治疗 PwD 的相关数据。使用 Stata16.0 软件进行荟萃分析。
我们旨在评估 VPM 在辅助治疗痴呆症患者中的疗效和安全性。
VPM 可能在痴呆症患者的治疗中发挥积极作用，本研究将为临床医生治疗 PwD 提供可靠的证据。
INPLASY 注册号：INPLASY2021110038（DOI：10.37766/inplasy2021.11.0038）。
