Department of Hematology, The Second Hospital of Jilin University, Changchun, China.
Medicine (Baltimore). 2021 Dec 23;100(51):e28262. doi: 10.1097/MD.0000000000028262.
This case report is presented to improve our understanding of the atypical immunophenotype of hairy cell leukemia.
A 58-year-old woman presented to our department with fatigue for >10 days.
The patient was diagnosed with an increased proportion of abnormal lymphocytes in peripheral blood and bone marrow smear, positive for CD11c, CD19, CD20, CD22, CD25, CD123, CD200, and Kappa, partial expression of CD23, but no expression of CD103, positive for BRAF V600E mutation.
Cladribine combined with rituximab achieved complete remission of minor residual disease negativity.
Hairy cell leukemia is rare, and the diagnosis and differential diagnosis should be made by combining the patient's medical history, clinical manifestations, immunophenotype, gene detection, and other means. Purine nucleoside analogs are the first-line treatments.
本病例报告旨在提高我们对毛细胞白血病非典型免疫表型的认识。
一位 58 岁女性因乏力超过 10 天就诊于我科。
患者外周血和骨髓涂片显示异常淋巴细胞比例增高，CD11c、CD19、CD20、CD22、CD25、CD123、CD200、Kappa 阳性，CD23 部分表达，CD103 不表达，BRAF V600E 突变阳性。
克拉屈滨联合利妥昔单抗治疗达到微小残留病灶阴性完全缓解。
毛细胞白血病罕见，诊断和鉴别诊断应结合患者的病史、临床表现、免疫表型、基因检测等手段。嘌呤核苷类似物是一线治疗药物。
