Colfax Oncology, Paterson, NJ, United States.
Department of Biological Sciences, Kean University, Union, NJ, United States.
Front Immunol. 2023 May 22;14:1207443. doi: 10.3389/fimmu.2023.1207443. eCollection 2023.
Hairy Cell Leukemia is an infrequent leukemia that can be recognized both microscopically and flow cytometrically once the patient develops symptoms. We present a case where early diagnosis was achieved using flow cytometry long before the patient became symptomatic. This was achieved by focusing on a small percentage (0.9%) of total leukocytes that exhibited a higher side scatter and brighter CD19/CD20 than the remaining lymphocytes. A bone marrow aspirate three weeks later confirmed the presence of malignant B-cells. Shortly after, the patient presented splenomegaly and complained of fatigue.
毛细胞白血病是一种罕见的白血病，一旦患者出现症状，即可通过显微镜检查和流式细胞术进行识别。我们报告了一个病例，在患者出现症状之前，通过流式细胞术很早就实现了早期诊断。这是通过关注总白细胞中一小部分（0.9％）实现的，这些细胞的侧向散射较高，CD19/CD20 比其余淋巴细胞更亮。三周后进行的骨髓抽吸术证实存在恶性 B 细胞。此后不久，患者出现了脾肿大并主诉疲劳。
