De Schepper Stijn, Gnanasegaran Gopinath, Dickson John C, Van den Wyngaert Tim
Department of Nuclear Medicine, Antwerp University Hospital, 2650 Edegem, Belgium.
Faculty of Medicine and Health Sciences (MICA-IPPON), University of Antwerp, 2610 Wilrijk, Belgium.
Diagnostics (Basel). 2021 Dec 11;11(12):2333. doi: 10.3390/diagnostics11122333.
The application of absolute quantification in SPECT/CT has seen increased interest in the context of radionuclide therapies where patient-specific dosimetry is a requirement within the European Union (EU) legislation. However, the translation of this technique to diagnostic nuclear medicine outside this setting is rather slow. Clinical research has, in some examples, already shown an association between imaging metrics and clinical diagnosis, but the applications, in general, lack proper validation because of the absence of a ground truth measurement. Meanwhile, additive manufacturing or 3D printing has seen rapid improvements, increasing its uptake in medical imaging. Three-dimensional printed phantoms have already made a significant impact on quantitative imaging, a trend that is likely to increase in the future. In this review, we summarize the data of recent literature to underpin our premise that the validation of diagnostic applications in nuclear medicine using application-specific phantoms is within reach given the current state-of-the-art in additive manufacturing or 3D printing.
在放射性核素治疗的背景下，绝对定量在SPECT/CT中的应用越来越受到关注，因为在欧盟立法中，患者特异性剂量测定是一项要求。然而，将这项技术应用于该领域之外的诊断核医学的进展相当缓慢。在一些案例中，临床研究已经显示出成像指标与临床诊断之间的关联，但总体而言，由于缺乏真实测量值，这些应用缺乏适当的验证。与此同时，增材制造或3D打印技术取得了快速进展，在医学成像中的应用也越来越多。三维打印体模已经对定量成像产生了重大影响，这一趋势在未来可能会进一步增强。在本综述中，我们总结了近期文献的数据，以支持我们的前提，即鉴于当前增材制造或3D打印的技术水平，使用特定应用体模对核医学诊断应用进行验证是可行的。
