Department of Radiology, Stanford Medical Center, Stanford, CA, USA.
Department of Physics, KTH Royal Institute of Technology, Stockholm, Sweden.
J Appl Clin Med Phys. 2021 Jun;22(6):183-190. doi: 10.1002/acm2.13263. Epub 2021 May 5.
We describe the creation and characterization of a calibration CT mini-lung-phantom incorporating simulated airways and ground-glass densities. Ten duplicate mini-lung-phantoms with Three-Dimensional (3-D) printed tubes simulating airways and gradated density polyurethane foam blocks were designed and built. Dimensional accuracy and CT numbers were measured using micro-CT and clinical CT scanners. Micro-CT images of airway tubes demonstrated an average dimensional variation of 0.038 mm from nominal values. The five different densities of incorporated foam blocks, simulating ground-glass, showed mean CT numbers (±standard deviation) of -897.0 ± 1.5, -844.1 ± 1.5, -774.1 ± 2.6, -695.3 ± 1.6, and -351.0 ± 3.7 HU, respectively. Three-Dimensional printing and subtractive manufacturing enabled rapid, cost-effective production of ground-truth calibration mini-lung-phantoms with low inter-sample variation that can be scanned simultaneously with the patient undergoing lung quantitative CT.
我们描述了一个校准 CT 迷你肺模型的创建和特征，该模型包含模拟气道和磨玻璃密度。设计并构建了十个具有三维（3-D）打印管的重复迷你肺模型，这些管模拟气道和梯度密度聚氨酯泡沫块。使用微 CT 和临床 CT 扫描仪测量尺寸精度和 CT 数。气道管的微 CT 图像显示平均尺寸变化为 0.038 毫米，偏离标称值。五个不同密度的合并泡沫块，模拟磨玻璃，显示平均 CT 数（±标准偏差）分别为-897.0±1.5、-844.1±1.5、-774.1±2.6、-695.3±1.6 和-351.0±3.7 HU。三维打印和减法制造能够快速、经济高效地生产具有低样品间变化的真实校准迷你肺模型，这些模型可以与接受肺部定量 CT 的患者一起进行扫描。
