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子宫动脉栓塞联合后续清宫术作为剖宫产瘢痕妊娠的低风险治疗方法

Uterine Artery Embolization Combined with Subsequent Suction Evacuation as Low-Risk Treatment for Cesarean Scar Pregnancy.

作者信息

Bohiltea Roxana, Ducu Ionita, Mihai Bianca, Iordache Ana-Maria, Dorobat Bogdan, Vladareanu Emilia Maria, Iordache Stefan-Marian, Bohiltea Alexia-Teodora, Bacalbasa Nicolae, Grigorescu Cristiana Eugenia Ana, Varlas Valentin

机构信息

Discipline of Obstetrics and Gynecology, "Carol Davila" University of Medicine and Pharmacy Bucharest, 37 Dionisie Lupu, 020021 Bucharest, Romania.

Department of Obstetrics and Gynecology, University Emergency Hospital Bucharest, 169 Splaiul Independentei Bld., Sector 5, 050098 Bucharest, Romania.

出版信息

Diagnostics (Basel). 2021 Dec 14;11(12):2350. doi: 10.3390/diagnostics11122350.

Abstract

OBJECTIVE

The aim of this study is to propose a standardized management of care for patients diagnosed with cesarean scar pregnancy (CSP). There are two types of CSP: Type 1 (on the scar) vs. type 2 (in the niche). To date there is no international standard to predict the extent of invasion or the optimal management of CSP.

MATERIALS AND METHODS

We used intramuscular methotrexate injection followed by uterine artery embolization combined with suction evacuation as a conservative approach for the treatment of seven patients diagnosed with CSP. Our inclusion criteria, to be satisfied simultaneously, were established as follows: (1) patients with CSP; (2) early gestational age ≤ 9 weeks, and (3) written consent of the proposed treatment of the patient.

RESULTS

This course of treatment produced a positive outcome in all cases. We did not have any complications (e.g., emergency hysterectomy, perforation of the uterine cavity, severe hemorrhage, or endometritis) during the procedures or in the follow-up. The most important predictors of successful management are early diagnosis of CSP and orientation of the invasive trophoblast opposite to the scar.

CONCLUSIONS

The main finding from this series of cases is that associating systemic methotrexate and uterine artery embolization provides efficient and low-risk management of CSP. This treatment regime is adequate for both types of CSPs. We consider that early localization diagnosis of pregnancy following a cesarean delivery is mandatory for CSP morbidity prevention.

摘要

目的

本研究旨在提出针对诊断为剖宫产瘢痕妊娠(CSP)患者的标准化护理管理方案。CSP有两种类型:1型(位于瘢痕上)和2型(位于肌壁间)。迄今为止,尚无预测CSP浸润程度或最佳管理方案的国际标准。

材料与方法

我们采用肌内注射甲氨蝶呤,随后行子宫动脉栓塞术并联合清宫术作为保守治疗方法,治疗7例诊断为CSP的患者。我们同时满足的纳入标准如下:(1)CSP患者;(2)孕早期≤9周,以及(3)患者对拟行治疗的书面同意。

结果

该治疗过程在所有病例中均产生了积极结果。在手术过程或随访期间,我们没有出现任何并发症(如急诊子宫切除术、子宫穿孔、严重出血或子宫内膜炎)。成功管理的最重要预测因素是CSP的早期诊断以及侵入性滋养层与瘢痕相对的方向。

结论

这一系列病例的主要发现是,联合全身应用甲氨蝶呤和子宫动脉栓塞术可提供高效且低风险的CSP管理。这种治疗方案适用于两种类型的CSP。我们认为,剖宫产术后早期进行妊娠定位诊断对于预防CSP发病至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6986/8700670/d130b74bffbb/diagnostics-11-02350-g001a.jpg

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