Fennell R H
Obstet Gynecol Surv. 1978 Jun;33(6):406-11. doi: 10.1097/00006254-197806000-00015.
MICA is the transition stage from intraepithelial growth to clinical invasive cancer. The early invasive growth must be accepted as an indication that the lesion is significant; it may be self-healing but it is objective evidence of progression and invasion remains the most significant indication of malignancy. The subjective changes of CIS, nuclear enlargement, pleomorphism of nuclei, altered nuclear-cytoplasmic ratio, etc., are transcended and the recognition and diagnosis of MICA should be facilitated for the pathologist. Treatment which tends to be conservative is more widely accepted, but the disease can be lethal and the most serious complication appears to be, like CIS, vaginal recurrence.
微浸润癌（MICA）是从上皮内生长到临床浸润癌的过渡阶段。早期浸润性生长必须被视为病变具有重要意义的指征；它可能会自行愈合，但它是病变进展的客观证据，而浸润仍然是恶性肿瘤最重要的指征。原位癌（CIS）的主观变化，如核增大、核多形性、核质比改变等已不再适用，这应有助于病理学家对微浸润癌的识别和诊断。倾向于保守的治疗方法更被广泛接受，但该疾病可能是致命的，而且最严重的并发症似乎与原位癌一样，是阴道复发。
