Yoshida S
Nihon Sanka Fujinka Gakkai Zasshi. 1981 Jan;33(1):127-35.
A pathological study of 142 cases of stage I carcinoma of the uterine cervix with a depth of invasion of less than 5 mm showed 119 of them, 104 stage Ia (87.4%) and 15 stage Ib (12.6%), to have a depth of invasion of less than 3 mm. As to the histological pattern of invasion in stage Ia, advanced bulky outgrowth from glands and early stromal invasion were observed at nearly the same frequency. Of 15 cases of stage Ib cervical carcinoma with depth of invasion of less than 3 mm, 10 were of reticular invasion, 4 were of "frühe Stroma-arrosion" and 1 was of vessel permeation. With either pattern of invasion, annular and longitudinal extension of the lesion tended to be wider in stage Ib than in stage Ia. Spread to the ectocervix was also wider in stage Ib. Modalities of treatment used for stage Ia carcinoma of the cervix were extended radical hysterectomy in 28 cases, sub-extended hysterectomy in 68 cases, simple hysterectomy in 3 cases, conization in 1 case and radiotherapy in 4 cases. Lymph node metastasis was noted in none of stage I cervical cancer cases with a radiotherapy in 4 cases. Lymph node metastasis was noted in none of stage I cervical cancer cases with a depth of invasion of less than 5 mm.
对142例浸润深度小于5mm的子宫颈I期癌进行的病理研究显示，其中119例（104例Ia期，占87.4%；15例Ib期，占12.6%）浸润深度小于3mm。关于Ia期的浸润组织学模式，腺体的晚期大块生长和早期间质浸润的出现频率几乎相同。在15例浸润深度小于3mm的Ib期子宫颈癌中，10例为网状浸润，4例为“早期间质侵蚀”，1例为血管浸润。无论哪种浸润模式，Ib期病变的环形和纵向扩展往往比Ia期更宽。Ib期向子宫颈外口的扩散也更广泛。Ia期子宫颈癌的治疗方式为：28例行广泛性子宫切除术，68例行次广泛性子宫切除术，3例行单纯子宫切除术，1例行锥形切除术，4例行放射治疗。4例行放射治疗的I期子宫颈癌病例均未发现淋巴结转移。浸润深度小于5mm的I期子宫颈癌病例均未发现淋巴结转移。
