Lippman S M, Grogan T M, Carry P, Ogden D A, Miller T P
Am J Med. 1987 Apr;82(4):814-6. doi: 10.1016/0002-9343(87)90020-9.
Immunosuppressed renal transplant recipients are at increased risk for large cell lymphoma of B cell phenotype. This report describes a case of post-transplantation lymphoma presenting with a mediastinal mass causing superior vena cava syndrome, tracheal obstruction, and pleural effusion. Cytospin preparations of pleural fluid documented high-grade lymphoblastic lymphoma morphology and immature T cell (cortical thymocyte) phenotype: Leu 1-6-positive, Leu 9-positive, Tdt-positive, B-negative, Calla-positive. The occurrence of post-transplantation lymphoma of T cell lineage is inconsistent with the postulated Epstein-Barr virus origin and raises important questions regarding the development of lymphoproliferative disorders in immunosuppressed organ transplant recipients.
免疫抑制的肾移植受者患B细胞表型大细胞淋巴瘤的风险增加。本报告描述了一例移植后淋巴瘤，表现为纵隔肿块，导致上腔静脉综合征、气管阻塞和胸腔积液。胸腔积液的细胞涂片显示为高级别淋巴母细胞淋巴瘤形态和未成熟T细胞（皮质胸腺细胞）表型：Leu 1 - 6阳性、Leu 9阳性、TdT阳性、B阴性、Calla阳性。T细胞系移植后淋巴瘤的发生与假定的爱泼斯坦 - 巴尔病毒起源不一致，并引发了关于免疫抑制器官移植受者淋巴增殖性疾病发展的重要问题。
