Griffith R C, Saha B K, Janney C M, Ratner L, Brunt E M, Gajl-Peczalska K J, Hanto D W
Department of Pathology, Miriam Hospital, Brown University, Providence, Rhode Island 02906.
Am J Clin Pathol. 1990 Feb;93(2):280-5. doi: 10.1093/ajcp/93.2.280.
A case of non-Hodgkin's lymphoma of T-cell type occurring in a renal transplant recipient is described. This lymphoma was classified as large cell, immunoblastic type and presented as a mediastinal mass, although it was demonstrated to be disseminated at autopsy two weeks later. Lymphoma cells expressed the immunologic profile of a mature, activated cytotoxic/suppressor T-lymphocyte. T-cell receptor gene rearrangement and karyotypic studies confirmed a clonal T-cell genotype. Molecular studies failed to demonstrate any association with Epstein-Barr virus or human T-cell lymphotropic virus type I or type II. Pathogenesis of lymphomas in this clinical setting is discussed.
本文描述了一例发生在肾移植受者中的T细胞型非霍奇金淋巴瘤。该淋巴瘤被分类为大细胞免疫母细胞型，表现为纵隔肿块，尽管两周后尸检显示已有播散。淋巴瘤细胞表达成熟活化细胞毒性/抑制性T淋巴细胞的免疫表型。T细胞受体基因重排和核型研究证实为克隆性T细胞基因型。分子研究未能证明与爱泼斯坦-巴尔病毒或人类T细胞嗜淋巴细胞病毒I型或II型有任何关联。本文还讨论了这种临床情况下淋巴瘤的发病机制。
