Jaśkowski Bartłomiej M, Opałka Adam, Gehrke Marek, Herudzińska Magdalena, Czeladko Jarosław, Baumgartner Walter, Jaśkowski Jędrzej M
Department of Reproduction and Clinic of Farm Animals, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland.
Department of Diagnostics and Clinical Sciences, Institute of Veterinary Medicine, Nicolaus Copernicus University, 87-100 Toruń, Poland.
Animals (Basel). 2021 Nov 24;11(12):3368. doi: 10.3390/ani11123368.
Assisted reproductive techniques in cattle, such as artificial insemination (AI) and embryo transfer (ET), are widely used. Despite many years of methodological improvements, the pregnancy rate (PR) in cows has not increased in direct proportion with their development. Among the possibilities to increase the PR is the use of certain steroids and nonsteroidal anti-inflammatory drugs (NSAIDs). The antiluteolytic effect of NSAIDs is achieved by blocking cyclooxygenase, which is involved in the conversion of arachidonic acid to prostaglandins. This article compares the PRs obtained after treatment with the commonly used NSAIDs in cattle, including flunixin meglumine, carprofen, meloxicam, ibuprofen, aspirin, and sildenafil. Studies on the effectiveness of certain steroid drugs on the PR have also been described. The results were not always consistent, and so comparisons between studies were made. In conclusion, flunixin meglumine seems to be an option, and can be recommended for improving ET results, especially in situations of high exposure or susceptibility to stress. Its administration under all circumstances, however, might be pointless and will not lead to the desired effect.
牛的辅助生殖技术，如人工授精（AI）和胚胎移植（ET），被广泛应用。尽管经过多年的方法改进，但奶牛的妊娠率（PR）并未随着这些技术的发展而直接成比例提高。提高妊娠率的可能方法之一是使用某些类固醇和非甾体抗炎药（NSAIDs）。NSAIDs的抗黄体溶解作用是通过阻断环氧化酶实现的，环氧化酶参与花生四烯酸向前列腺素的转化。本文比较了牛使用常用NSAIDs（包括氟尼辛葡甲胺、卡洛芬、美洛昔康、布洛芬、阿司匹林和西地那非）治疗后的妊娠率。还描述了某些类固醇药物对妊娠率有效性的研究。结果并不总是一致的，因此对各研究进行了比较。总之，氟尼辛葡甲胺似乎是一种选择，可推荐用于改善胚胎移植结果，特别是在高暴露或易受应激的情况下。然而，在所有情况下使用它可能毫无意义，也不会产生预期效果。
