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用于实验动物科学课程的大鼠和小鼠模拟器的解剖学评估

Anatomical Evaluation of Rat and Mouse Simulators for Laboratory Animal Science Courses.

作者信息

Corte Giuliano M, Humpenöder Melanie, Pfützner Marcel, Merle Roswitha, Wiegard Mechthild, Hohlbaum Katharina, Richardson Ken, Thöne-Reineke Christa, Plendl Johanna

机构信息

Institute of Veterinary Anatomy, Department of Veterinary Medicine, Freie Universität Berlin, 14195 Berlin, Germany.

Institute of Animal Welfare, Animal Behavior and Laboratory Animal Science, Department of Veterinary Medicine, Freie Universität Berlin, 14163 Berlin, Germany.

出版信息

Animals (Basel). 2021 Dec 1;11(12):3432. doi: 10.3390/ani11123432.

DOI:10.3390/ani11123432
PMID:34944209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8697941/
Abstract

According to the European Directive 63/2010/EU, education and training involving living rats and mice are classified as an animal experiment and demands the implementation of the 3Rs. Therefore, as a method of refinement, rat and mouse simulators were developed to serve as an initial training device for various techniques, prior to working on living animals. Nevertheless, little is known about the implementation, anatomical correctness, learning efficiency and practical suitability of these simulators. With this in mind, a collaborative research project called "SimulRATor" was initiated to systematically evaluate the existing rat and mouse simulators in a multi-perspective approach. The objective of the study presented here was to identify the anatomical strengths and weaknesses of the available rat and mouse simulators and to determine anatomical requirements for a new anatomically correct rat simulator, specifically adapted to the needs of Laboratory Animal Science (LAS) training courses. Consequently, experts of Veterinary Anatomy and LAS evaluated the anatomy of all currently available rat and mouse simulators. The evaluation showed that compared to the anatomy of living rats and mice, the tails were perceived as the most anatomically realistic body part, followed by the general exterior and the limbs. The heads were rated as the least favored body part.

摘要

根据欧洲指令63/2010/EU，涉及活体大鼠和小鼠的教育与培训被归类为动物实验，并要求实施3R原则。因此，作为一种优化方法，大鼠和小鼠模拟器被开发出来，作为在对活体动物进行操作之前，用于各种技术初步培训的设备。然而，对于这些模拟器的实施情况、解剖学正确性、学习效率和实际适用性，人们了解甚少。考虑到这一点，一个名为“SimulRATor”的合作研究项目启动了，旨在从多视角系统评估现有的大鼠和小鼠模拟器。本文所述研究的目的是确定现有大鼠和小鼠模拟器在解剖学上的优缺点，并确定一种专门适应实验动物科学（LAS）培训课程需求的、解剖学正确的新型大鼠模拟器的解剖学要求。因此，兽医解剖学和LAS领域的专家对所有现有的大鼠和小鼠模拟器的解剖结构进行了评估。评估结果表明，与活体大鼠和小鼠的解剖结构相比，尾巴被认为是解剖学上最逼真的身体部位，其次是整体外观和四肢。头部被评为最不受青睐的身体部位。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/1ddba9868ba8/animals-11-03432-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/f595f5b0fe0b/animals-11-03432-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/8a257afa17e7/animals-11-03432-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/495a3cfd3904/animals-11-03432-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/069df66ae592/animals-11-03432-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/9e4d566b9135/animals-11-03432-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/bd1f253f8476/animals-11-03432-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/1f24397de234/animals-11-03432-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/a1c911c11338/animals-11-03432-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/1ddba9868ba8/animals-11-03432-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/f595f5b0fe0b/animals-11-03432-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/8a257afa17e7/animals-11-03432-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/495a3cfd3904/animals-11-03432-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/069df66ae592/animals-11-03432-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/9e4d566b9135/animals-11-03432-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/bd1f253f8476/animals-11-03432-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/1f24397de234/animals-11-03432-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/a1c911c11338/animals-11-03432-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d5/8697941/1ddba9868ba8/animals-11-03432-g009.jpg

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J Vis Exp. 2017 Dec 10(130):55852. doi: 10.3791/55852.
3
Airway management education: simulation based training versus non-simulation based training-A systematic review and meta-analyses.
Brain Sci. 2022 Dec 5;12(12):1671. doi: 10.3390/brainsci12121671.
4
Three-Dimensional Interactive Graphical Model of the Hindlimb Muscles of the Rat.大鼠后肢肌肉的三维交互式图形模型。
Cells Tissues Organs. 2023;212(3):215-219. doi: 10.1159/000523708. Epub 2022 Feb 24.
气道管理教育：基于模拟的培训与非基于模拟的培训——一项系统评价和荟萃分析
BMC Anesthesiol. 2017 Feb 1;17(1):17. doi: 10.1186/s12871-017-0313-7.
4
Evaluation of Mice Undergoing Serial Oral Gavage While Awake or Anesthetized.对清醒或麻醉状态下接受连续灌胃的小鼠的评估。
J Am Assoc Lab Anim Sci. 2016 Nov;55(6):805-810.
5
Teaching of diagnostic skills in equine gynecology: simulator-based training versus schooling on live horses.马妇科诊断技能教学：基于模拟器的培训与在活马身上的训练
Theriogenology. 2015 Oct 15;84(7):1088-95. doi: 10.1016/j.theriogenology.2015.06.007. Epub 2015 Jun 20.
6
Development and Evaluation of Two Canine Low-Fidelity Simulation Models.两种犬类低保真模拟模型的开发与评估
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7
Development and evaluation of a canine laparoscopic simulator for veterinary clinical training.用于兽医临床培训的犬腹腔镜模拟器的开发与评估。
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8
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9
The effects of repeated oral gavage on the health of male CD-1 mice.重复经口灌胃对雄性 CD-1 小鼠健康的影响。
Lab Anim (NY). 2012 May;41(5):129-34. doi: 10.1038/laban0512-129.
10
Degrees of reality: airway anatomy of high-fidelity human patient simulators and airway trainers.逼真程度：高保真人体模拟患者和气道训练器的气道解剖结构。
Anesthesiology. 2012 Jun;116(6):1204-9. doi: 10.1097/ALN.0b013e318254cf41.