Viland H, Blomgren H
Anticancer Res. 1987 Jan-Feb;7(1):17-22.
RU 41.740 (Biostim) is an extract of Klebsiella pneumoniae with immunomodulating properties. This substance was observed to augment spontaneous cytotoxicity of human blood lymphocytes provided that monocytes were present during Biostim treatment. Maximal augmentation was observed after 2 h of incubation. The F1 fraction, a glucoprotein which comprises approximately 20% of Biostim, and LPS from Klebsiella pneumoniae were also observed to augment spontaneous cytotoxicity of lymphocytes. Biostim treatment of K562 cells, which were used as target cells for killing, did not change their sensitivity to the lytic action of spontaneously cytotoxic cells.
RU 41.740（生物刺激素）是一种具有免疫调节特性的肺炎克雷伯菌提取物。观察到该物质可增强人血淋巴细胞的自发细胞毒性，前提是在生物刺激素处理期间存在单核细胞。孵育2小时后观察到最大增强效果。还观察到F1组分（一种约占生物刺激素20%的糖蛋白）和肺炎克雷伯菌的脂多糖可增强淋巴细胞的自发细胞毒性。将K562细胞作为杀伤靶细胞进行生物刺激素处理，并未改变其对自发细胞毒性细胞裂解作用的敏感性。
