[抗炎药和免疫刺激剂对迟发型超敏反应的影响]
[Effect of anti-inflammatory agents and immunostimulants on delayed hypersensitivity].
作者信息
Bogdanova A Sh
出版信息
Antibiot Med Biotekhnol. 1987 Feb;32(2):148-50.
Combination of nonnarcotic analgetics (antiphlogistic drugs) such as acetylsalicylic acid, indomethacin, voltaren and naproxen and immunostimulators such as prodigiozan, levamisole and methyluracil were studied with respect to their effect on delayed type hypersensitivity (DTH) to dinitrochlorobenzene (DNCB) in noninbred albino rats of both sexes. The drugs were administered after sensitization. It was shown that prodigiozan did not change DTH to DNCB. Levamisole and methyluracil lowered DTH to DNCB. The effect of levamisole was preserved in the presence of indomethacin and voltaren. Indomethacin and voltaren inhibited DTH. Acetylsalicylic acid and naproxen did not change it. Prodigiozan, methyluracil and levamisole did not change the character of the effect of the above antiphlogistic drugs on DTH.
研究了非麻醉性镇痛药（抗炎药）如乙酰水杨酸、吲哚美辛、扶他林和萘普生与免疫刺激剂如灵菌红素、左旋咪唑和甲基尿嘧啶联合使用对非近交系雌雄白化大鼠二硝基氯苯（DNCB）迟发型超敏反应（DTH）的影响。这些药物在致敏后给药。结果表明，灵菌红素不改变对DNCB的DTH。左旋咪唑和甲基尿嘧啶降低了对DNCB的DTH。在吲哚美辛和扶他林存在的情况下，左旋咪唑的作用得以保留。吲哚美辛和扶他林抑制DTH。乙酰水杨酸和萘普生不改变DTH。灵菌红素、甲基尿嘧啶和左旋咪唑不改变上述抗炎药对DTH的作用特性。
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