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[免疫刺激剂联合应用作为纠正继发性免疫缺陷的一种方法]

[A combination of immunostimulants as a method for correcting secondary immunodeficiencies].

作者信息

Alekhin E K, Lazareva D N, Bogdanova A Sh, Riabchinskaia L A, Mufazalova N A, Khasanova D D

出版信息

Eksp Klin Farmakol. 1993 Mar-Apr;56(2):39-42.

PMID:8348038
Abstract

The specific features of the action of combinations of immunostimulants (levamisole, prodigiozan, methyluracil) on a primary immune response to EB, GST and resistance to experimental infection have been studied. It has been shown that levamisole eliminates stimulation by methyluracil and prodigiozan of a primary immune response, lithium carbonate is also an antagonist of prodigiozan. Vitamin E increases the stimulating effect of prodigiozan rather than oxymethacil. The effect of vitamin A depends on the dose. Levamisole does not change the influence of prodigiozan and methyluracil on GST and, like prodigiozan, suppresses GST stimulated by lithium carbonate. The combination of prodigiozan and methyluracil to a large extent than the agent given alone increases resistance to an infection and efficiency of antibiotic therapy. The combination of methyluracil and levamisole increases only the effect of the antibiotic.

摘要

研究了免疫刺激剂(左旋咪唑、灵菌红素、甲基尿嘧啶)组合对EB的初次免疫反应、谷胱甘肽S-转移酶(GST)以及对实验性感染抵抗力的作用特点。结果表明,左旋咪唑消除了甲基尿嘧啶和灵菌红素对初次免疫反应的刺激作用,碳酸锂也是灵菌红素的拮抗剂。维生素E增强了灵菌红素而非氧甲苄嘧啶的刺激作用。维生素A的作用取决于剂量。左旋咪唑不改变灵菌红素和甲基尿嘧啶对GST的影响,并且与灵菌红素一样,抑制碳酸锂刺激的GST。灵菌红素与甲基尿嘧啶的组合比单独使用该药物在很大程度上更能提高对感染的抵抗力和抗生素治疗的效果。甲基尿嘧啶与左旋咪唑的组合仅增强了抗生素的效果。

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