Matthaios Dimitrios, Tolia Maria, Mauri Davide, Kamposioras Konstantinos, Karamouzis Michalis
Department of Medical Oncology, Rhodes General Hospital, 85100 Rhodes, Greece.
Department of Radiotherapy, School of Medicine, University of Crete, 71500 Heraklion, Greece.
Biomedicines. 2021 Dec 20;9(12):1949. doi: 10.3390/biomedicines9121949.
Hippo pathway with its main molecule YAP is a crucial pathway for development, tissue homeostasis, wound healing, tissue regeneration, and cancer. In this review, we discuss the multiple effects of the YAP/Hippo pathway in the immune system and cancer. We analyzed a series of effects: extracellular vesicles enhanced immunity through inhibition of LATS1/2, ways of modulation of the tumor microenvironment, YAP- and TAZ-mediated upregulation of PDL1, high expression of YAP and PDL1 in EGFR-TKI-resistant cells, enhanced YAP activity in inflammation, and the effect of the Hippo pathway on T cells, B cells, Tregs, macrophages, and myeloid-derived suppressor cells (MDSCs). These pleiotropic effects render the YAP and Hippo pathway a key pathway for exploitation in the future, in order to enhance our immunotherapy treatment strategies in oncology.
具有主要分子YAP的Hippo信号通路是发育、组织稳态、伤口愈合、组织再生和癌症的关键信号通路。在本综述中，我们讨论了YAP/Hippo信号通路在免疫系统和癌症中的多种作用。我们分析了一系列作用：细胞外囊泡通过抑制LATS1/2增强免疫力、调节肿瘤微环境的方式、YAP和TAZ介导的PDL1上调、EGFR-TKI耐药细胞中YAP和PDL1的高表达、炎症中YAP活性增强以及Hippo信号通路对T细胞、B细胞、调节性T细胞、巨噬细胞和骨髓来源的抑制性细胞（MDSC）的作用。这些多效性作用使YAP和Hippo信号通路成为未来有待开发的关键信号通路，以便增强我们在肿瘤学中的免疫治疗策略。
