使用正电子发射断层扫描测量甲状腺的辐射剂量。

Measurement of radiation dose to the thyroid using positron emission tomography.

作者信息

Ott R J, Batty V, Webb B S, Flower M A, Leach M O, Clack R, Marsden P K, McCready V R, Bateman J E, Sharma H

出版信息

Br J Radiol. 1987 Mar;60(711):245-51. doi: 10.1259/0007-1285-60-711-245.

Abstract

Measurements of the functioning volume of thyroid tissue have been made in 22 patients undergoing radioiodine therapy for thyrotoxicosis, using a prototype multiwire proportional counter positron camera. Tomographic images were produced of the distribution of 124I in the thyroid. Functioning volumes were found to be in the range 21-79 cm3 with volume errors of the order of +/- 4% to +/- 14%. Radioiodine uptake varied from 28% to 98%. Using a value of 6 days for the effective half-life of radioiodine in hyperactive thyroids, radiation doses from a standard therapy administration of 75 MBq of 131I varied from 11 to 48 Gy (compared with a recommended 50-70 Gy). In five cases PET imaging showed a non-uniform distribution of radioiodine in thyroids thought to have uniform uptake from conventional pinhole scintigraphy.

摘要

利用一台原型多丝正比计数器正电子相机，对22例因甲状腺毒症接受放射性碘治疗的患者的甲状腺组织功能体积进行了测量。生成了甲状腺中¹²⁴I分布的断层图像。发现功能体积在21 - 79立方厘米范围内，体积误差约为±4%至±14%。放射性碘摄取率从28%到98%不等。对于功能亢进的甲状腺，使用放射性碘有效半衰期为6天的值，75兆贝可的¹³¹I标准治疗剂量产生的辐射剂量在11至48戈瑞之间（相比之下，推荐剂量为50 - 70戈瑞）。在5例病例中，PET成像显示甲状腺中放射性碘分布不均匀，而传统针孔闪烁扫描认为摄取是均匀的。