Pages Pierre-Benoit, Cottenet Jonathan, Bonniaud Philippe, Tubert-Bitter Pascale, Piroth Lionel, Cadranel Jacques, Bernard Alain, Quantin Catherine
Department of Thoracic Surgery, Centre Hospitalier Universitaire Dijon, Bocage Central, 21079 Dijon, France.
INSERM UMR 1231, Centre Hospitalier Universitaire Bocage, University of Burgundy, 21079 Dijon, France.
Cancers (Basel). 2021 Dec 14;13(24):6277. doi: 10.3390/cancers13246277.
Few studies have investigated the link between SARS-CoV-2 and health restrictions and its effects on the health of lung cancer (LC) patients. The aim of this study was to assess the impact of the SARS-CoV-2 epidemic on surgical activity volume, postoperative complications and in-hospital mortality (IHM) for LC resections in France. All data for adult patients who underwent pulmonary resection for LC in France in 2020, collected from the national administrative database, were compared to 2018-2019. The effect of SARS-CoV-2 on the risk of IHM and severe complications within 30 days among LC surgery patients was examined using a logistic regression analysis adjusted for age, sex, comorbidities and type of resection. There was a slight decrease in the volume of LC resections in 2020 ( = 11,634), as compared to 2018 ( = 12,153) and 2019 ( = 12,227), with a noticeable decrease in April 2020 (the peak of the first wave of epidemic in France). We found that SARS-CoV-2 (0.43% of 2020 resections) was associated with IHM and severe complications, with, respectively, a sevenfold (aOR = 7.17 (3.30-15.55)) and almost a fivefold (aOR = 4.76 (2.31-9.80)) increase in risk. Our study suggests that LC surgery is feasible even during a pandemic, provided that general guidance protocols edited by the surgical societies are respected.
很少有研究调查严重急性呼吸综合征冠状病毒2（SARS-CoV-2）与健康限制之间的联系及其对肺癌（LC）患者健康的影响。本研究的目的是评估SARS-CoV-2疫情对法国LC切除术的手术活动量、术后并发症和住院死亡率（IHM）的影响。从国家行政数据库收集的2020年在法国接受LC肺切除术的成年患者的所有数据与2018 - 2019年的数据进行了比较。使用针对年龄、性别、合并症和切除类型进行调整的逻辑回归分析，研究了SARS-CoV-2对LC手术患者30天内IHM风险和严重并发症的影响。与2018年（= 12,153）和2019年（= 12,227）相比，2020年LC切除术的数量略有下降（= 11,634），2020年4月（法国第一波疫情高峰）有明显下降。我们发现，SARS-CoV-2（占2020年切除术的0.43%）与IHM和严重并发症相关，风险分别增加了七倍（调整后比值比[aOR] = 7.17（3.30 - 15.55））和近五倍（aOR = 4.76（2.31 - 9.80））。我们的研究表明，即使在大流行期间，只要遵守外科协会编辑的一般指导方案，LC手术也是可行的。
