Czarnecki Damian, Ziółkowski Marcin, Chodkiewicz Jan, Długosz Anna, Feldheim Joanna, Waszkiewicz Napoleon, Kułak-Bejda Agnieszka, Gorzkiewicz Marta, Budzyński Jacek, Junkiert-Czarnecka Anna, Siomek-Górecka Agnieszka, Nicpoń Krzysztof, Kawala-Sterniuk Aleksandra, Ferri Raffaele, Pelc Mariusz, Walecki Piotr, Laskowska Ewa, Gorzelańczyk Edward Jacek
Department of Preventive Nursing, Collegium Medicum, Nicolaus Copernicus University, Torun, ul. Ignacego Łukasiewicza 1, 85-821 Bydgoszcz, Poland.
Institute of Psychology, Department of Clinical Psychology and Psychopathology, University of Lodz, ul. Smugowa 10/12, 91-433 Łódź, Poland.
J Clin Med. 2021 Dec 15;10(24):5892. doi: 10.3390/jcm10245892.
The main aim of this work was to determine the impact of COMT and DRD2 gene polymorphisms together with temperament and character traits on alcohol craving severity alcohol-dependent persons. The sample comprised of 89 men and 16 women (aged 38±7). For the sake of psychological assessment various analytic methods have been applied like the Short Alcohol Dependence Data Questionnaire (SADD), Penn Alcohol Craving Scale (PACS) or Temperament and Character Inventory (TCI) test. The SNP polymorphism of the analyzed genes was determined by Real Time PCR test. The results showed, that the COMT polymorphismmay have an indirected relationship with the intensity and changes in alcohol craving during abstinence. The DRD2 receptor gene polymorphisms are related with the intensity of alcohol craving. It seems that the character traits like "self-targeting", including "self-acceptance", are more closely related to the severity of alcohol craving and polymorphic changes in the DRD2 receptor than temperamental traits. Although this is a pilot study the obtained results appeared to be promising and clearly indicate the link betweengene polymorphisms alcohol craving and its severity.
这项工作的主要目的是确定儿茶酚-O-甲基转移酶（COMT）和多巴胺D2受体（DRD2）基因多态性以及气质和性格特征对酒精依赖者酒精渴望严重程度的影响。样本包括89名男性和16名女性（年龄38±7岁）。为了进行心理评估，应用了各种分析方法，如简短酒精依赖数据问卷（SADD）、宾夕法尼亚酒精渴望量表（PACS）或气质和性格量表（TCI）测试。通过实时聚合酶链反应（PCR）测试确定所分析基因的单核苷酸多态性（SNP）。结果表明，COMT基因多态性可能与戒酒期间酒精渴望的强度和变化存在间接关系。DRD2受体基因多态性与酒精渴望的强度有关。似乎“自我导向”等性格特征，包括“自我接纳”，与酒精渴望的严重程度以及DRD2受体的多态性变化比气质特征更为密切相关。尽管这是一项初步研究，但所获得的结果似乎很有前景，并清楚地表明了基因多态性、酒精渴望及其严重程度之间的联系。
