Lehmann Felix, Schenk Lorena M, Bernstock Joshua D, Bode Christian, Borger Valeri, Gessler Florian, Güresir Erdem, Hamed Motaz, Potthoff Anna-Laura, Putensen Christian, Schneider Matthias, Zimmermann Julian, Vatter Hartmut, Schuss Patrick, Hadjiathanasiou Alexis
Department of Anesthesiology and Intensive Care, University Hospital Bonn, 53127 Bonn, Germany.
Department of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.
J Clin Med. 2021 Dec 17;10(24):5939. doi: 10.3390/jcm10245939.
The impact of dehydration at admission of patients with spontaneous intracerebral hemorrhage (ICH) on short-term mortality remains ambiguous due to scarce data. All of the consecutive patients with spontaneous ICH, who were referred to our neurovascular center in 2018/19, were assessed for hydration status on admission. Dehydration was defined by a blood urea-to-creatinine ratio > 80. In a cohort of 249 patients, 76 patients (31%) were dehydrated at the time of admission. The following factors were significantly and independently associated with increased 30-day mortality in multivariate analysis: "signs of cerebral herniation" ( = 0.008), "initial midline shift > 5 mm" ( < 0.001), "ICH score > 3" ( = 0.007), and "admission dehydration status" ( = 0.007). The results of the present study suggest that an admission dehydration status might constitute a significant and independent predictor of short-term mortality in patients with spontaneous ICH.
由于数据稀缺，自发性脑出血（ICH）患者入院时脱水对短期死亡率的影响仍不明确。对2018/19年转诊至我们神经血管中心的所有连续性自发性ICH患者进行了入院时水化状态评估。脱水定义为血尿素与肌酐比值>80。在249例患者队列中，76例（31%）患者入院时存在脱水。多因素分析显示，以下因素与30天死亡率增加显著且独立相关：“脑疝体征”（P = 0.008）、“初始中线移位>5mm”（P < 0.001）、“ICH评分>3”（P = 0.007）和“入院脱水状态”（P = 0.007）。本研究结果表明，入院脱水状态可能是自发性ICH患者短期死亡率的一个显著且独立的预测因素。
