Papotti Bianca, Macchi Chiara, Favero Chiara, Iodice Simona, Adorni Maria Pia, Zimetti Francesca, Corsini Alberto, Aliberti Stefano, Blasi Francesco, Carugo Stefano, Bollati Valentina, Vicenzi Marco, Ruscica Massimiliano
Department of Food and Drug, University of Parma, 43124 Parma, Italy.
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20100 Milan, Italy.
J Clin Med. 2021 Dec 18;10(24):5955. doi: 10.3390/jcm10245955.
A number of studies have highlighted important alterations of the lipid profile in COVID-19 patients. Besides the well-known atheroprotective function, HDL displays anti-inflammatory, anti-oxidative, and anti-infectious properties. The aim of this retrospective study was to assess the HDL anti-inflammatory and antioxidant features, by evaluation of HDL-associated Serum amyloid A (SAA) enrichment and HDL-paraoxonase 1 (PON-1) activity, in a cohort of COVID-19 patients hospitalized at the Cardiorespiratory COVID-19 Unit of Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico of Milan. COVID-19 patients reached very low levels of HDL-c (mean ± SD: 27.1 ± 9.7 mg/dL) with a marked rise in TG (mean ± SD: 165.9 ± 62.5 mg/dL). Compared to matched-controls, SAA levels were significantly raised in COVID-19 patients at admission. There were no significant differences in the SAA amount between 83 alive and 22 dead patients for all-cause in-hospital mortality. Similar findings were reached in the case of PON-1 activity, with no differences between alive and dead patients for all-cause in-hospital mortality. In conclusion, although not related to the prediction of in-hospital mortality, reduction in HDL-c and the enrichment of SAA in HDL are a mirror of SARS-CoV-2 positivity even at the very early stages of the infection.
多项研究强调了新冠病毒肺炎（COVID-19）患者血脂谱的重要改变。除了众所周知的抗动脉粥样硬化保护功能外，高密度脂蛋白（HDL）还具有抗炎、抗氧化和抗感染特性。本回顾性研究的目的是，通过评估HDL相关血清淀粉样蛋白A（SAA）富集情况和HDL对氧磷酶1（PON-1）活性，来评估一组在米兰 Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico医院心肺COVID-19科室住院的COVID-19患者中HDL的抗炎和抗氧化特征。COVID-19患者的HDL-c水平极低（平均值±标准差：27.1±9.7mg/dL），甘油三酯（TG）显著升高（平均值±标准差：165.9±62.5mg/dL）。与匹配的对照组相比，COVID-19患者入院时SAA水平显著升高。在83名存活患者和22名因各种原因院内死亡的患者之间，SAA量没有显著差异。PON-1活性情况也有类似发现，存活患者和死亡患者在各种原因院内死亡率方面没有差异。总之，虽然与院内死亡率的预测无关，但HDL-c降低和HDL中SAA富集是SARS-CoV-2阳性的反映，即使在感染的极早期阶段也是如此。
