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术前跌倒风险评估分数作为食管癌患者食管切除术后的一个预后因素

Preoperative Fall Risk Assessment Score as a Prognostic Factor in Esophageal Cancer Patients after Esophagectomy.

作者信息

Kouzu Keita, Tsujimoto Hironori, Ishibashi Yusuke, Shinada Hanae, Oikawa Isawo, Kishi Yoji, Shinomiya Nariyoshi, Ueno Hideki

机构信息

Department of Surgery, National Defense Medical College, Saitama 359-0042, Japan.

Department of Integrative Physiology and Bio-Nano Medicine, Saitama 359-0042, Japan.

出版信息

J Clin Med. 2021 Dec 19;10(24):5966. doi: 10.3390/jcm10245966.

Abstract

The current study investigated the impact of preoperative fall risk assessment score (FRAS) on long-term prognoses in patients with esophageal cancer (EC). A total of 161 patients with EC who underwent curative surgery were classified into a high-risk (95, 41.0%) and low-risk (66, 41.0%) groups according to their FRAS. This study investigated the relationships between the FRAS and clinicopathological findings and prognoses. Accordingly, patients in the high-risk group were significantly older and had a significantly higher Charlson comorbidity index than those in the low-risk group. No significant difference was found in pathological findings between both groups. The high-risk group had significantly lower overall survival (OS) and relapse-free survival (RFS) rates than the low-risk group ( = 0.004 and 0.001, respectively). Multivariate analysis identified high FRAS as an independent prognostic factor for poor OS, with a hazard ratio of 1.75 ( = 0.033). Moreover, re-analysis of the data after excluding age as a category showed that the high-risk group had significantly worse OS ( = 0.004) and RFS ( = 0.003) than the low-risk group. The FRAS can, therefore, be considered a useful method for assessing frailty and a potential prognostic factor for EC.

摘要

本研究调查了术前跌倒风险评估评分(FRAS)对食管癌(EC)患者长期预后的影响。共有161例行根治性手术的EC患者根据其FRAS被分为高风险组(95例,41.0%)和低风险组(66例,41.0%)。本研究调查了FRAS与临床病理特征及预后之间的关系。因此,高风险组患者的年龄显著更大,Charlson合并症指数也显著高于低风险组。两组之间的病理结果未发现显著差异。高风险组的总生存期(OS)和无复发生存期(RFS)率显著低于低风险组(分别为 = 0.004和0.001)。多因素分析确定高FRAS是OS不良的独立预后因素,风险比为1.75( = 0.033)。此外,在排除年龄这一分类后重新分析数据显示,高风险组的OS( = 0.004)和RFS( = 0.003)显著差于低风险组。因此,FRAS可被认为是评估虚弱程度的一种有用方法,也是EC的一个潜在预后因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38bc/8709201/0290aeb87d07/jcm-10-05966-g001.jpg

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