Kouzu Keita, Tsujimoto Hironori, Ishibashi Yusuke, Shinada Hanae, Oikawa Isawo, Kishi Yoji, Shinomiya Nariyoshi, Ueno Hideki
Department of Surgery, National Defense Medical College, Saitama 359-0042, Japan.
Department of Integrative Physiology and Bio-Nano Medicine, Saitama 359-0042, Japan.
J Clin Med. 2021 Dec 19;10(24):5966. doi: 10.3390/jcm10245966.
The current study investigated the impact of preoperative fall risk assessment score (FRAS) on long-term prognoses in patients with esophageal cancer (EC). A total of 161 patients with EC who underwent curative surgery were classified into a high-risk (95, 41.0%) and low-risk (66, 41.0%) groups according to their FRAS. This study investigated the relationships between the FRAS and clinicopathological findings and prognoses. Accordingly, patients in the high-risk group were significantly older and had a significantly higher Charlson comorbidity index than those in the low-risk group. No significant difference was found in pathological findings between both groups. The high-risk group had significantly lower overall survival (OS) and relapse-free survival (RFS) rates than the low-risk group ( = 0.004 and 0.001, respectively). Multivariate analysis identified high FRAS as an independent prognostic factor for poor OS, with a hazard ratio of 1.75 ( = 0.033). Moreover, re-analysis of the data after excluding age as a category showed that the high-risk group had significantly worse OS ( = 0.004) and RFS ( = 0.003) than the low-risk group. The FRAS can, therefore, be considered a useful method for assessing frailty and a potential prognostic factor for EC.
本研究调查了术前跌倒风险评估评分(FRAS)对食管癌(EC)患者长期预后的影响。共有161例行根治性手术的EC患者根据其FRAS被分为高风险组(95例,41.0%)和低风险组(66例,41.0%)。本研究调查了FRAS与临床病理特征及预后之间的关系。因此,高风险组患者的年龄显著更大,Charlson合并症指数也显著高于低风险组。两组之间的病理结果未发现显著差异。高风险组的总生存期(OS)和无复发生存期(RFS)率显著低于低风险组(分别为 = 0.004和0.001)。多因素分析确定高FRAS是OS不良的独立预后因素,风险比为1.75( = 0.033)。此外,在排除年龄这一分类后重新分析数据显示,高风险组的OS( = 0.004)和RFS( = 0.003)显著差于低风险组。因此,FRAS可被认为是评估虚弱程度的一种有用方法,也是EC的一个潜在预后因素。