Hooper D C, Young J L, Elson C J, Taylor R B
Cell Immunol. 1987 Apr 15;106(1):53-61. doi: 10.1016/0008-8749(87)90149-3.
Normal mice are shown to harbor T cells that can be sensitized to proliferate against autologous red blood cells (RBC). These autoreactive cells were primed in vitro and in vivo with mouse as well as heterologous rat RBC, the in vivo administration of which has been previously shown to trigger the production of auto-RBC antibodies. Two broad classes of specificity are detected following priming: T cells cross-reactive for similar determinants coexpressed by mouse and rat RBC, and T cells specific for antigens restricted to self-RBC. These findings indicate that clonal deletion of self-RBC-reactive T cells is far from complete. The comparison of different in vitro and in vivo immunization protocols revealed the possible existence of several levels of immunoregulatory control which may prevent the expression of autoimmunity by these T cells.
正常小鼠体内存在可被致敏以针对自身红细胞（RBC）增殖的T细胞。这些自身反应性细胞在体外和体内用小鼠以及异源大鼠红细胞进行致敏，先前已表明体内给予这些红细胞会触发自身红细胞抗体的产生。致敏后检测到两类广泛的特异性：对小鼠和大鼠红细胞共表达的相似决定簇具有交叉反应性的T细胞，以及对限于自身红细胞的抗原具有特异性的T细胞。这些发现表明，自身红细胞反应性T细胞的克隆清除远未完全。对不同体外和体内免疫方案的比较揭示了可能存在几个免疫调节控制水平，这可能会阻止这些T细胞表达自身免疫性。
