University of Ljubljana, Faculty of Pharmacy, Aškerčeva Cesta 7, 1000 Ljubljana, Slovenia.
Comenius University in Bratislava, Faculty of Pharmacy, 83232 Bratislava, Slovakia.
Molecules. 2021 Dec 8;26(24):7421. doi: 10.3390/molecules26247421.
Herbal products are often used as an alternative to pharmacological therapy. Menopausal symptoms and gynecological disorders (such as premenstrual syndrome and dysmenorrhea) are the indications where pharmacological therapy may have serious adverse events, hence many women prefer to use herbal products to help with these symptoms. Here, we reviewed plants and derived products, which are commonly used for the abovementioned indications, focusing on clinical data, safely profile and whether or not their use is justified. We noted that limited data are available on the use of some plants for alleviating the symptoms of menopause and gynecological disorders. While black cohosh () and red clover () were consistently shown to help reduce menopausal symptoms in clinical studies, currently available data do not fully support the use of fenugreek (), hops (), valerian (), and soybean ( and ) for this indication. For premenstrual syndrome and premenstrual dysphoric disorder, chaste tree () shows effectiveness, but more clinical studies are needed to confirm such effect upon the use of evening primrose ().
草药产品常被用作药理学治疗的替代方法。绝经期症状和妇科疾病(如经前期综合征和痛经)是药理学治疗可能产生严重不良反应的指征,因此许多女性更愿意使用草药产品来缓解这些症状。在这里,我们综述了常用于上述适应证的植物及其衍生产品,重点关注临床数据、安全性概况以及使用的合理性。我们注意到,关于一些植物用于缓解绝经期和妇科疾病症状的使用数据有限。黑升麻()和红三叶草()在临床研究中被一致证明有助于减轻绝经期症状,而目前的可用数据并不完全支持使用胡芦巴()、啤酒花()、缬草()和大豆(和)用于该适应证。对于经前期综合征和经前期烦躁障碍,圣约翰草()显示出有效性,但需要更多的临床研究来证实月见草()在使用时的这种效果。