Mehrpooya Maryam, Rabiee Soghra, Larki-Harchegani Amir, Fallahian Amir-Mohammad, Moradi Abbas, Ataei Sara, Javad Masoumeh Taravati
Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Obstetrics and Gynecology, School of Medicine, Hamadan University of Medical Science, Hamadan, Iran.
J Educ Health Promot. 2018 Mar 1;7:36. doi: 10.4103/jehp.jehp_81_17. eCollection 2018.
Hot flashes are considered to be a common experience for menopausal women and they can compromise the quality of life. The objective of this study is to assess the efficacy of in comparison with evening primrose oil (EPO) in postmenopausal women with menopause-related symptoms.
This study was performed on 80 postmenopausal women with hot flashes. The participants were randomly divided into two groups by blocked randomization. The participants of one group received black cohosh and the other group received EPO for 8 weeks. The severity and number of hot flashes and quality of life were measured by four-point scale, and the Menopause-Specific Quality of Life (MENQOL) questionnaire at pre-intervention, 1, 4, and 8 weeks after treatment. Data were analyzed in SPSS Version 16 using independent -test, Chi-square, and Fisher's exact test.
Average severity of hot flashes in both groups and number of hot flashes in black cohosh group in 8 week were significantly lower than 1 week ( < 0.001), but number of hot flashes in primrose oil group in 8 week showed no significant differences ( = 0.32). The number of hot flashes and quality of life score in black cohosh arm compared to EPO showed a significant decrease in the 8 week ( < 0.05). All MENQOL scores were significantly improved in two groups ( < 0.05), but the percentage of improvement in black cohosh arm was significantly superior to EPO group.
Both herbs were effective in reduction of severity of hot flashes and improvement of the quality of life, but it seems that black cohosh is more effective than primrose oil because it was able to reduce the number of hot flashes too.
潮热被认为是绝经后女性的常见经历,会影响生活质量。本研究的目的是评估[具体药物名称未给出]与月见草油(EPO)相比,对有绝经相关症状的绝经后女性的疗效。
本研究对80名有潮热症状的绝经后女性进行。参与者通过区组随机化被随机分为两组。一组参与者服用黑升麻,另一组服用EPO,为期8周。在干预前、治疗后1周、4周和8周,通过四点量表以及绝经特异性生活质量(MENQOL)问卷来测量潮热的严重程度、潮热次数和生活质量。使用SPSS 16版软件,采用独立样本t检验、卡方检验和Fisher精确检验对数据进行分析。
两组潮热的平均严重程度以及黑升麻组8周时的潮热次数均显著低于1周时(P<0.001),但月见草油组8周时的潮热次数无显著差异(P = 0.32)。与EPO相比,黑升麻组8周时的潮热次数和生活质量得分显著降低(P<0.05)。两组的所有MENQOL得分均显著改善(P<0.05),但黑升麻组的改善百分比显著优于EPO组。
两种草药都能有效减轻潮热严重程度并改善生活质量,但黑升麻似乎比月见草油更有效,因为它还能减少潮热次数。