三种地中海植物精油的化学成分和生物活性分析。
Chemical and Bioactive Characterization of the Essential Oils Obtained from Three Mediterranean Plants.
机构信息
Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.
REQUIMTE/LAQV, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
出版信息
Molecules. 2021 Dec 10;26(24):7472. doi: 10.3390/molecules26247472.
L., L. and L. are Mediterranean arboreal and shrub species that possess essential oils (EO) in their leaves and branches. This study aimed at characterizing the EOs obtained by steam distillation from the three species collected in different locations from Spain (Almazán, Andévalo, Barriomartín, Cerezal, Ermitas and Huéscar). For this purpose, volatiles composition was determined by GC-MS, and different bioactivities were evaluated. The highest content in terpenes was observed in (Huéscar origin) followed by (Almazán origin), corresponding to 92% and 91.9% of total compounds, respectively. With exception of from Cerezal that presented viridiflorol as the most abundant compound, all the three species presented in common the α-pinene as the major compound. The EOs from showed high antibacterial potential, presenting MIC values from 0.3 to 1.25 mg/mL. Concerning other bioactivities, EO revealed an oxidation inhibition of 83%, while showed cytotoxicity in the MCF-7 cell line, and and EOs exhibited the highest potential on NCI-H460 cell lines. Nevertheless, some EOs revealed toxicity against non-tumoral cells but generally presented a GI value higher than that of the tumor cell lines.
L.、L. 和 L. 是地中海地区的乔木和灌木物种，其叶片和枝条中含有精油 (EO)。本研究旨在对从西班牙不同地区（阿尔马赞、安达瓦洛、巴里奥马丁、谢雷萨尔、埃尔米塔斯和韦尔卡萨尔）采集的三种物种通过水蒸气蒸馏获得的 EO 进行表征。为此，通过 GC-MS 确定了挥发物的组成，并评估了不同的生物活性。萜烯含量最高的是来自 Huéscar 的 L.（92%），其次是来自 Almazán 的 L.（91.9%），分别对应于总化合物的 92%和 91.9%。除了 Cerezal 的 L.，它以绿花白千层醇为最丰富的化合物外，所有三种物种都有共同的特征，即α-蒎烯是主要化合物。L. 的 EO 表现出很强的抗菌潜力，MIC 值从 0.3 到 1.25 mg/mL。关于其他生物活性，L. 的 EO 表现出 83%的氧化抑制作用，而 L. 和 L. 的 EO 对 MCF-7 细胞系表现出细胞毒性，L. 和 L. 的 EO 对 NCI-H460 细胞系表现出最大的潜力。然而，一些 EO 对非肿瘤细胞表现出毒性，但通常具有高于肿瘤细胞系的 GI 值。
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