Herodin F, Laval J D, Fatome M, Fauve R M
Int J Radiat Biol Relat Stud Phys Chem Med. 1987 Mar;51(3):549-59. doi: 10.1080/09553008714551021.
Protection against 8.7 Gy whole-body gamma-irradiation (lethal in 100 per cent of mice by 30 days) was observed in 90 per cent of mice bearing a one-day-old granuloma induced by polyacrylamide beads. When the inflammatory reaction was induced sooner or later a lower or null protection was obtained. A dose-effect relationship between the volume of injected beads and resulting radioprotection was established. The radioprotective effect depends only on the acute non-specific inflammation since hydrocortisone acetate injected into mice before the beads abolished this protection. This inflammatory pattern led to a dose reduction factor of 1.36 +/- 0.08 (P less than 0.05) for LD 50/30. A 90 per cent survival was observed in mice bearing a one-day-old granuloma when they were injected 1 h before 10 Gy with the granuloma acellular eluate (P less than 0.02 compared to a 50 per cent survival observed with polyacrylamide beads alone). Substances with a molecular weight higher than 300,000 are involved in the synergistic radioprotective effect of the granuloma-eluate association.
在90%携带由聚丙烯酰胺珠诱导形成的1日龄肉芽肿的小鼠中，观察到对8.7 Gy全身γ射线照射（30天内可使100%的小鼠致死）具有防护作用。当炎症反应诱导时间提前或推迟时，获得的防护作用降低或消失。建立了注射珠的体积与产生的辐射防护之间的剂量效应关系。辐射防护作用仅取决于急性非特异性炎症，因为在注射珠之前给小鼠注射醋酸氢化可的松可消除这种防护作用。这种炎症模式使LD50/30的剂量降低系数为1.36±0.08（P<0.05）。当携带1日龄肉芽肿的小鼠在接受10 Gy照射前1小时注射肉芽肿无细胞洗脱液时，观察到90%的存活率（与单独使用聚丙烯酰胺珠时观察到的50%存活率相比，P<0.02）。分子量高于300,000的物质参与了肉芽肿洗脱液联合的协同辐射防护作用。
