Miranda-Massari Jorge R, Toro Alondra P, Loh Doris, Rodriguez Jose R, Borges Raul Morales, Marcial-Vega Victor, Olalde Jose, Berdiel Miguel J, Riordan Neil H, Martinez Juan Manuel, Gil Armando, Gonzalez Michael J
Medical Sciences Campus, School of Pharmacy, University of Puerto Rico, San Juan, PR 00936, USA.
Program of Naturopathic Sciences, DP University, San Juan, PR 00918, USA.
Life (Basel). 2021 Dec 3;11(12):1341. doi: 10.3390/life11121341.
Currently available anti-viral drugs may be useful in reducing the viral load but are not providing the necessary physiological effects to reduce the SARS-CoV-2 complications efficiently. Treatments that provide better clinical outcomes are urgently needed. Vitamin C (ascorbic acid, AA) is an essential nutrient with many biological roles that have been proven to play an important part in immune function; it serves as an antioxidant, an anti-viral, and exerts anti-thrombotic effects among many other physiological benefits. Research has proven that AA at pharmacological doses can be beneficial to patients with acute respiratory distress syndrome (ARDS) and other respiratory illnesses, including sepsis. In addition, High-Dose Intravenous Vitamin C (HDIVC) has proven to be effective in patients with different viral diseases, such as influenza, chikungunya, Zika, and dengue. Moreover, HDIVC has been demonstrated to be very safe. Regarding COVID-19, vitamin C can suppress the cytokine storm, reduce thrombotic complications, and diminish alveolar and vascular damage, among other benefits. Due to these reasons, the use of HDIVC should be seriously considered in complicated COVID-19 patients. In this article, we will emphasize vitamin C's multiple roles in the most prominent pathophysiological processes presented by the COVID-19 disease.
目前可用的抗病毒药物可能有助于降低病毒载量，但无法提供必要的生理效应来有效减少新冠病毒并发症。迫切需要能带来更好临床结果的治疗方法。维生素C（抗坏血酸，AA）是一种必需营养素，具有多种生物学作用，已被证明在免疫功能中发挥重要作用；它具有抗氧化、抗病毒作用，还具有抗血栓形成等多种生理益处。研究证明，药理剂量的AA对急性呼吸窘迫综合征（ARDS）和其他呼吸系统疾病（包括败血症）患者有益。此外，高剂量静脉注射维生素C（HDIVC）已被证明对患有不同病毒性疾病（如流感、基孔肯雅热、寨卡病毒病和登革热）的患者有效。而且，HDIVC已被证明非常安全。对于新冠肺炎，维生素C可以抑制细胞因子风暴，减少血栓形成并发症，并减轻肺泡和血管损伤等。由于这些原因，对于复杂的新冠肺炎患者，应认真考虑使用HDIVC。在本文中，我们将强调维生素C在新冠肺炎所呈现的最突出病理生理过程中的多种作用。
