人类衰老。由抗神经节苷脂单克隆抗体3G5定义的新型T细胞亚群呈线性增加。
Aging in man. Linear increase of a novel T cell subset defined by antiganglioside monoclonal antibody 3G5.
作者信息
Rabinowe S L, Nayak R C, Krisch K, George K L, Eisenbarth G S
出版信息
J Exp Med. 1987 May 1;165(5):1436-41. doi: 10.1084/jem.165.5.1436.
Abstract
A new human T cell subset defined by antineuronal ganglioside mAb 3G5 increases linearly with advancing age in man. The percentage of circulating 3G5+ T cells in 21 normal individuals, quantitated by cytofluorograph analysis, increases linearly from age 7 (23-30%) to age 84 (58%) (r = 0.85, p less than 0.001). The antigen on T cells has the biochemical properties of a ganglioside that migrates between GM1 and GM2 ganglioside markers on TLC. The 3G5 subset represents the first T cell subset that reflects aging in man.
摘要
一种由抗神经元神经节苷脂单克隆抗体3G5定义的新型人类T细胞亚群在人类中随年龄增长呈线性增加。通过细胞荧光分析定量检测的21名正常个体中循环3G5 + T细胞的百分比，从7岁时的23 - 30%线性增加到84岁时的58%（r = 0.85，p < 0.001）。T细胞上的抗原具有神经节苷脂的生化特性，在薄层层析上介于GM1和GM2神经节苷脂标记物之间迁移。3G5亚群是第一个反映人类衰老的T细胞亚群。
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本文引用的文献
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