研究由不同粘附强度的平板基底诱导的囊泡的形状变化。

Investigation of Shape Transformations of Vesicles, Induced by Their Adhesion to Flat Substrates Characterized by Different Adhesion Strength.

机构信息

Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.

Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, 1000 Ljubljana, Slovenia.

出版信息

Int J Mol Sci. 2021 Dec 14;22(24):13406. doi: 10.3390/ijms222413406.

DOI:10.3390/ijms222413406

PMID:34948201

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8706551/

Abstract

The adhesion of lipid vesicles to a rigid flat surface is investigated. We examine the influence of the membrane spontaneous curvature, adhesion strength, and the reduced volume on the stability and shape transformations of adhered vesicles. The minimal strength of the adhesion necessary to stabilize the shapes of adhered vesicles belonging to different shape classes is determined. It is shown that the budding of an adhered vesicle may be induced by the change of the adhesion strength. The importance of the free vesicle shape for its susceptibility to adhesion is discussed.

摘要

我们研究了脂质囊泡在刚性平面上的附着。考察了膜的自发曲率、附着强度和排挤体积对附着囊泡的稳定性和形状转变的影响。确定了使属于不同形状类别的附着囊泡稳定所需的最小附着强度。结果表明，附着囊泡的出芽可以通过附着强度的变化来诱导。讨论了自由囊泡形状对其易附着性的重要性。