Institute of Physical Chemistry Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.
J Chem Phys. 2011 Jan 14;134(2):024110. doi: 10.1063/1.3530069.
The attachment of macromolecules to the surface of a lipid vesicle may cause its deformations such as budding or creation of cylindrical protrusions. Diffusion of the macromolecules in the membranes may cause its shape transformations. The process of shrinking the protrusions due to diffusion of the macromolecules is investigated. It is assumed that macromolecules modify locally the spontaneous curvature and bending rigidity of the lipid membrane. Both spontaneous curvature and bending rigidities depend on the concentration of membrane components. It has been shown that cylindrical protrusions are created when the macromolecules which induce large spontaneous curvature are accumulated at a piece of the vesicle surface. It has been observed that here the elastic constants influence very little the evolution of the vesicle shape caused by diffusing macromolecules and the most important is the value the spontaneous curvature imposed by the macromolecules.
大分子与脂质囊泡表面的附着可能导致其变形，例如出芽或形成圆柱形突起。大分子在膜中的扩散可能导致其形状发生变化。研究了由于大分子扩散导致突起收缩的过程。假设大分子局部改变脂质膜的自发曲率和弯曲刚度。自发曲率和弯曲刚度都取决于膜成分的浓度。已经表明，当在囊泡表面的一部分积聚诱导大的自发曲率的大分子时，会形成圆柱形突起。已经观察到，在这里，弹性常数对由扩散的大分子引起的囊泡形状的演变影响很小，最重要的是由大分子施加的自发曲率的值。
