Chang J Y, Duara R, Barker W, Apicella A, Finn R
J Nucl Med. 1987 May;28(5):852-60.
We have developed a method that allows two sets of regional cerebral metabolic rates of glucose (rCMRglc) to be obtained in a single extended procedure using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG). This is an adaptation of the deoxyglucose method, with the addition of a second injection of FDG immediately after completion of the first scan, then followed 30 min later by a second scan. A model has been developed to allow for correction of measured tracer concentration in the second scan by subtracting the predicted remnant from the first scan. The possible applications of this method in studying behavior-metabolism relationships are demonstrated. The preliminary results show 6%-12% changes in rCMRglc values for appropriate brain regions when the behavioral state is altered, but show 0%-5% change in rCMRglc values when the behavioral state is unchanged. The method can contribute significantly to the understanding of behavior-metabolism relationships by allowing the noninvasive study of two behavioral states in a single PET procedure.
我们开发了一种方法，该方法可通过正电子发射断层扫描（PET）和[18F]氟脱氧葡萄糖（FDG），在一个延长的程序中获得两组局部脑葡萄糖代谢率（rCMRglc）。这是对脱氧葡萄糖方法的一种改进，即在第一次扫描完成后立即额外注射一次FDG，然后在30分钟后进行第二次扫描。已经开发出一种模型，通过从第一次扫描中减去预测的残留量来校正第二次扫描中测量的示踪剂浓度。展示了该方法在研究行为-代谢关系中的可能应用。初步结果表明，当行为状态改变时，相应脑区的rCMRglc值有6%-12%的变化，但当行为状态未改变时，rCMRglc值有0%-5%的变化。该方法通过在单次PET程序中对两种行为状态进行无创研究，可对理解行为-代谢关系做出重大贡献。
