Rust T C, DiBella E V R, McGann C J, Christian P E, Hoffman J M, Kadrmas D J
Utah Center for Advanced Imaging Research, Department of Radiology and Department of Bioengineering, CAMT, 729 Arapeen Drive, University of Utah, Salt Lake City, UT 84108-1218, USA.
Phys Med Biol. 2006 Oct 21;51(20):5347-62. doi: 10.1088/0031-9155/51/20/018. Epub 2006 Oct 3.
Quantification of myocardial blood flows at rest and stress using 13N-ammonia PET is an established method; however, current techniques require a waiting period of about 1 h between scans. The objective of this study was to test a rapid dual-injection single-scan approach, where 13N-ammonia injections are administered 10 min apart during rest and adenosine stress. Dynamic PET data were acquired in six human subjects using imaging protocols that provided separate single-injection scans as gold standards. Rest and stress data were combined to emulate rapid dual-injection data so that the underlying activity from each injection was known exactly. Regional blood flow estimates were computed from the dual-injection data using two methods: background subtraction and combined modelling. The rapid dual-injection approach provided blood flow estimates very similar to the conventional single-injection standards. Rest blood flow estimates were affected very little by the dual-injection approach, and stress estimates correlated strongly with separate single-injection values (r=0.998, mean absolute difference=0.06 ml min-1 g-1). An actual rapid dual-injection scan was successfully acquired in one subject and further demonstrates feasibility of the method. This study with a limited dataset demonstrates that blood flow quantification can be obtained in only 20 min by the rapid dual-injection approach with accuracy similar to that of conventional separate rest and stress scans. The rapid dual-injection approach merits further development and additional evaluation for potential clinical use.
使用(^{13}N) - 氨正电子发射断层扫描（PET）定量静息和负荷状态下的心肌血流量是一种成熟的方法；然而，目前的技术在两次扫描之间需要约1小时的等待时间。本研究的目的是测试一种快速双注射单扫描方法，即在静息和腺苷负荷期间，两次(^{13}N) - 氨注射相隔10分钟进行。使用成像协议在六名人类受试者中采集动态PET数据，该协议提供单独的单注射扫描作为金标准。将静息和负荷数据合并以模拟快速双注射数据，从而精确了解每次注射的基础活性。使用两种方法从双注射数据计算区域血流量估计值：背景减法和联合建模。快速双注射方法提供的血流量估计值与传统单注射标准非常相似。静息血流量估计值受双注射方法的影响很小，负荷估计值与单独的单注射值密切相关（(r = 0.998)，平均绝对差(= 0.06 ml min^{-1} g^{-1})）。在一名受试者中成功获得了实际的快速双注射扫描，进一步证明了该方法的可行性。这项数据集有限的研究表明，通过快速双注射方法仅需20分钟即可获得血流量定量，其准确性与传统的单独静息和负荷扫描相似。快速双注射方法值得进一步开发和进行潜在临床应用的额外评估。
