Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul 06973, Korea.
Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea.
Int J Environ Res Public Health. 2021 Dec 10;18(24):13059. doi: 10.3390/ijerph182413059.
To evaluate the effect of tonsillectomy on the subsequent risk of pneumonia in an adult population, a longitudinal follow-up case control study was conducted using a national health screening cohort dataset between 2003 and 2012. A total of 1005 tonsillectomy participants were 1:4 matched with 4020 control participants for age, sex, income, and region of residence. The number of pneumonia diagnoses were counted from the index date (ID) to the date after the first-year (post-ID 1y), second-year (post-ID 2y), and third-year (post-ID 3y) periods. Simple linear regression and multiple linear regression were conducted to calculate estimated values (EVs) and 95% confidence intervals for each post-ID pneumonia and compared between the two groups. Subgroup analyses were performed according to age, sex, and the number of pneumonia cases during the year prior to the ID (pre-ID 1y). In the simple linear regression model, post-ID pneumonia did not show a significant correlation with tonsillectomy (post-ID 1y: EV = 0.003; post-ID 2y: EV = 0.007; post-ID 3y: EV = 0.013; all > 0.05). In the multiple regression model, post-ID pneumonia also did not show a significant correlation with tonsillectomy (post-ID 1y: EV = 0.001; post-ID 2y: EV = 0.006; post-ID 3y: EV = 0.011; all > 0.05). In the subgroup analyses, tonsillectomy did not show a significant correlation with post-ID pneumonia in either the simple linear regression or multiple linear regression models (all > 0.05). Tonsillectomy performed in the adult population did not show any effect in increasing the incidence of pneumonia during the first three postoperative years.
为了评估扁桃体切除术对成年人群随后肺炎风险的影响，我们进行了一项纵向随访病例对照研究，使用了 2003 年至 2012 年期间的国家健康筛查队列数据集。共有 1005 名扁桃体切除术患者与 4020 名对照参与者按年龄、性别、收入和居住地区域进行 1:4 匹配。从索引日期（ID）到术后第一年（post-ID 1y）、第二年（post-ID 2y）和第三年（post-ID 3y），计算肺炎诊断的数量。简单线性回归和多元线性回归分别用于计算每个 post-ID 肺炎的估计值（EV）及其 95%置信区间，并在两组之间进行比较。根据年龄、性别和 ID 前一年（pre-ID 1y）的肺炎例数进行亚组分析。在简单线性回归模型中，post-ID 肺炎与扁桃体切除术无显著相关性（post-ID 1y：EV = 0.003；post-ID 2y：EV = 0.007；post-ID 3y：EV = 0.013；均>0.05）。在多元回归模型中，post-ID 肺炎与扁桃体切除术也无显著相关性（post-ID 1y：EV = 0.001；post-ID 2y：EV = 0.006；post-ID 3y：EV = 0.011；均>0.05）。在亚组分析中，无论是简单线性回归还是多元线性回归模型，扁桃体切除术与 post-ID 肺炎均无显著相关性（均>0.05）。在成年人群中进行的扁桃体切除术不会增加术后三年内肺炎的发生率。
